Recombinant immunotoxins are chimeric proteins in which a truncated toxin is fused to a recombinant antigen-binding domain such as a recombinant Fv or Fab. Recombinant immunotoxins target cell surface receptors and other antigens on tumor cells. The antigen-binding and -targeting domains in recombinant immunotoxins are usually single-chain Fvs (scFv), which are the antibody variable regions con...

The use of brackish waters is an alternative for the cultivation fruit-bearing plants in semi-arid regions; nonetheless, sweetsop trees (Annona squamosa L.) are sensitive to these types waters. However, phosphate fertilization can be a technique used mitigate harmful effects salinity. Thus, our objective was evaluate application phosphorus salinity irrigation water. experiment conducted randomi...

changes in chlorophyll florescence is one of the physiological responses of plants to waterlogging stress. due to easily measured in field and its inexpensive and non-destructive characteristics, it is one of the best ways to assess different genotypes tolerance to stresses. in this experiment, trends of chlorophyll fluorescence index (fv/fm) of ‘satsuma’ mandarin (citrus unshiu) on seven roots...

Recombinant immunotoxins are fusion proteins composed of Fv regions of antibodies and bacterial or plant toxins that are being developed for the targeted therapy of cancer. MR1(Fv)-PE38 is a single-chain recombinant immunotoxin that targets a mutant form of the epidermal growth factor receptor (EGFR), EGFRvIII, that is frequently overexpressed in malignant glioblastomas. We have used random com...

This research is motivated by the demands of stakeholders on companies to implement sustainability. On other hand, there management's reluctance it, because they perceive that implementation sustainability not directly related company's main activities.The purpose this analyze effect corporate sustainable development (CSD) firm value (FV) and size (FS) through profitability (P) as a mediating v...

Red spruce (Picea rubens Sarg.) and black spruce (Picea mariana (Mill.) B.S.P.) are genetically and morphologically similar but ecologically distinct species. We determined intraspecific seed-source and interspecific variation of red spruce and black spruce, from across the near-northern margins of their ranges, for several light-energy processing and freezing-tolerance adaptive traits. Before ...

The authors examined the associations between placental vascular findings and preterm delivery in 1,053 subcohort women (239 preterm, 814 term) from a Michigan pregnancy cohort study (1998-2004). Twenty-nine placental vascular variables from microscopic examinations were grouped into 5 constructs: 3 maternal constructs-obstructive lesions (MV-O), bleeding/vessel integrity (MV-I), and lack of ph...

Introduction. Follicular variant (FV) papillary thyroid carcinoma (PTC) has aggressive biologic behavior as compared to classic variant (CV) of PTC and frequently metastasizes to the lungs and bones. However, metastasis to the pancreas is extremely rare manifestation of FV-PTC. To date, only 9 cases of PTC have been reported in the literature. Pancreatic metastases from PTC usually remain asymp...

Activated protein C (APC) resistance is a major risk factor for venous thrombosis. Factor V (FV) gene mutations like FV(Leiden) (R506Q) and FV(R2) (H1299R) may cause APC resistance either by reducing the susceptibility of FVa to APC-mediated inactivation or by interfering with the cofactor activity of FV in APC-catalyzed FVIIIa inactivation. We quantified the APC cofactor activity expressed by ...