Chronic venous disease encompasses a broad range of conditions from minor telangiectasia to varicose veins to severe venous insufficiency with venous ulcers. The common underlying mechanism for chronic venous disease is congestion and stasis caused by reversal of venous flow and valve failure. Patients with primary varicose veins have venous congestion limited to the superficial venous system, ...

Chronic venous insufficiency is characterized by cutaneous alterations caused by venous hypertension; in severe forms, it progresses to lower limb ulcers. Lower limb varicose veins are the main cause of chronic venous insufficiency, and the classic treatment includes surgery and compressive therapy. Minimally invasive alternative treatments for varicose veins include new techniques such as veno...

BACKGROUND Despite the high prevalence of chronic venous insufficiency and varicose veins in the Western world, suitable pharmaceutical therapies for these venous diseases have not been explored to date. In this context, we recently reported that a chronic increase in venous wall stress or biomechanical stretch is sufficient to cause development of varicose veins through the activation of the t...

varicose veins are an extremely common medical condition (present in 5-30% of adults). surgery remains the gold standard of care in patients with varicose veins, however several newer interventions have been recently introduced which need to be evaluated. during the standard surgery it is imperative to demonstrate and ligate the tributaries of the saphenofemoral junction in combination with str...

BACKGROUND Although widely applied, the cost-effectiveness of endovenous laser ablation (EVLT) for varicose veins has not been established. METHODS Cost-effectiveness analysis was performed on the evaluation of EVLT for the treatment of uncomplicated varicose veins by using published data from randomizd clinical trials regarding the costs and the quality of life. Incremental cost per quality-...

PURPOSE To determine the frequency of pelvic varicose veins with transvaginal ultrasound and associated lower extremity venous insufficiency with Doppler ultrasound in women with chronic pelvic pain of undetermined origin. MATERIALS AND METHODS A total of 100 women with chronic pelvic pain of undetermined origin lasting more than 6 months were included in the study. The presence of anechogeni...

PURPOSE Varicose veins with great saphenous vein (GSV) insufficiency is prevalent. Among various surgical treatments for varicose veins, cryosurgery of GSV is an alternative minimally invasive technique that could leave fewer scars and replace conventional stripping with ambulatory phlebectomy. This study sought to assess outcomes including efficacy and safety of cryosurgery for varicose veins....

Varicose veins are an early manifestation of chronic venous insufficiency. Although the risk factors associated with varicose veins are well described, the basic pathophysiology leading to venous valvular incompetence, and thus, varicosities are less well known. However, cosmetics aside, the leg fatigue and heaviness that is associated with chronic venous insufficiency in the presence of varico...

A weakening of the venous valves and walls is a common cause varicose veins. Blood might flow back pool in veins due to damaged valves, causing them enlarge. Weakened vein are longer, broader, less elastic than normal, valve flaps split, resulting increased blood pooling twisted Primary characterised by valvular incompetence reflux, which have long been assumed be cause. Recent research, on oth...

Oxygen levels (tension, saturation, and content) in blood from varicose leg veins were found to be significantly lower than those in blood from normal leg veins at the same site on the limb under the same laboratory conditions. Treatment with hydroxyethylrutosides significantly increased the oxygen levels in blood from varicose veins, and this was associated with an improvement in leg symptoms ...