Objective: To compare the flow of the left internal thoracic artery under a local pharmacological effect caused by the topical action on the arterial pedicle and the intraluminal effect of a calcium channel blocker with a control group using papaverine. Methods: Over a period from July to November 2004, a prospective study was performed involving 73 patients who were submitted to coronary arter...

We compared the renal vascular responses to angiotensin converting enzyme inhibition and renin inhibition to assess the influence of angiotensin II (Ang II). We examined the renal and endocrine responses to the renin inhibitor enalkiren, to captopril, and to placebo in nine healthy and nine hypertensive men on a 10-mmol sodium diet. Ang II was infused to assess effects of the agents on renal an...

Diese Dissertation wurde selbständig und ohne unerlaubte Hilfsmittel angefertigt. (2005). The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia. (2006). Characterisation of the Ste20-like kinase Krs1 of Dictyostelium discoideum. Eur. (2003) STE20-like kinases and their role in the actin cytoskeleton in Dictyostelium discoideum. The Ste20-like kinase DST1...

INDICATIONS AND USAGE INOmax is a vasodilator, which, in conjunction with ventilatory support and other appropriate agents, is indicated for the treatment of term and near-term (>34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension, where it improves oxygenation and reduces the need for extracorporeal memb...

Nitrosothiols are powerful vasodilators. Although the mechanism of their formation near neutral pH is an area of intense research, neither the energetics nor the kinetics of this reaction or of subsequent reactions have been addressed. The following considerations may help to guide experiments. (1) The standard Gibbs energy for the homolysis reaction RSNO → RS(•) + NO(•)(aq) is +110 ± 5 kJ mol(...

1. A method is described for the measurement of forearm blood flow during sustained voluntary isometric hand-grip contractions that can be maintained constant by the subject’s monitoring of the strength of his contractions. 2. In most subjects it was found that contractions of 5% of their maximal voluntary force could be maintained without fatigue, and without any post-exercise increase in bloo...

A case is cited in which hydrallazine was used in conjunction with volume expansion as a novel approach to the improvement of orthostatic symptoms in a patient with idiopathic postural hypotension.

Sex and age have important influences on sympathetic neural control of blood pressure in humans. Young women are relatively protected against risk of hypertension due to greater peripheral vasodilator influences compared with young men and older people. This protective effect is lost at menopause. Older men and women have higher sympathetic nerve activity and tighter coupling between SNA and bl...