In past studies conducted by our group, riparin I (rip I) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice, while its analogs rip II and III showed anxiolytic and antidepressant-like actions. This time around, we investigated a possible antidepressant activity of rip I using the forced swimming test (FST) and tail suspension test (TST) as predictive tests for...

The opioid system has been implicated in major depression and in the mechanism of action of antidepressants. This study investigated the involvement of the opioid system in the antidepressant-like effect of the water-soluble B-vitamin folic acid in the forced swimming test (FST). The effect of folic acid (10 nmol/site, i.c.v.) was prevented by the pretreatment of mice with naloxone (1 mg/kg, i....

There is evidence to support a relationship between stress, depression, and alcoholism. Animal models have been developed to ascertain the impact of stress on depressive-like symptoms and ethanol intake. The swim test susceptible (SUS) line of rats selectively bred for enhanced susceptibility to stress-induced immobility in the forced swim test (FST) also show high voluntarily ethanol intake co...

Hypercortisolemia is one of the clinical features found in depressed patients. This clinical feature has been mimicked in animal studies via application of exogenous corticosterone (CORT). Previous studies suggested that CORT can induce behavioral disturbance in anxious-depressive like behavior, which is associated with suppressed neurogenesis. Hippocampal neurogenesis plays an important role i...

BACKGROUND Follistatin (FST), a single chain glycoprotein, is originally isolated from follicular fluid of ovary. Previous studies have revealed that serum FST served as a biomarker for pregnancy and ovarian mucinous tumor. However, whether FST can serve as a biomarker for diagnosis in lung adenocarcinoma of humans remains unclear. METHODS AND RESULTS The study population consisted of 80 pati...

Objective: The purpose of this study was to determine the activity and optimal dose Muntingia calabura L. ethanol extract as an antidepressant using Forced Swimming Test (FST), Tail Suspensions (TST), Open Field (OFT).
 Methods: Twenty-five male Swiss-Webster mice were randomly divided into five groups. Group 1 a control group, got vehicle (1% w/v CMC). As positive control, group 2 0.052 m...

Objective: The goal of the present study was to assess antidepressant-like action Withania qaraitica in two behavioral animal models, forced-swimming test (FST) and tail suspension (TST) mice. Methods: methanolic extract prepared by maceration. antidepressant activity measured using C57BL/6 mice BALB/c Mice were divided into three groups: control (DMSO), standard (citalopram desipramine), (n = ...

OBJECTIVE To identify and quantify frontal sharp transients found in neonatal polysomnography of healthy full term newborns in each stage of the sleep-wake cycle within the first 48 hours of life. METHOD The EEG from healthy term 32 newborns, legal age of two days and with adequate monitoring during pregnancy. Frontal sharp transients (FST) were quantified, according to synchronous or asynchr...

We investigated the antidepressant-like effect of lactoferrin (Lf) in a repeated forced-swim test (FST) stress mouse model. FST was performed on days 1, 2, 7 and 14. Bovine Lf (bLf) or bovine serum albumin (BSA) was supplemented at 1% to the commercial diet after the first FST throughout the experimental period. The FST-control and FST+BSA group showed a marked increase in immobility time on da...