Xanthohumol (XN), a simple prenylated chalcone, can be isolated from hops and has the potential to be a cancer chemopreventive agent against several human tumor cell lines. We previously identified valosin-containing protein (VCP) as a target of XN; VCP can also play crucial roles in cancer progression and prognosis. Therefore, we investigated the molecular mechanisms governing the contribution...

Objective. Despite preservation of the recurrent laryngeal nerve (RLN), transient vocal cord paralysis (VCP) occurs after 1.2% to 10.9% of thyroidectomies. The objective of this study was to study risk factors for transient VCP after thyroidectomy. Study Design. Prospective cohort study. Setting. Academic teaching hospital. Subjects and Methods. Two hundred fifteen consecutive thyroid surgeries...

During periods of crisis, cells must compensate to survive. To this end, may need alter the subcellular localization crucial proteins. Here, we show that during starvation, VCP, most abundant soluble ATPase, relocalizes and forms aggregate-like structures at perinuclear regions in PC3 prostate cancer cells. This movement is associated with a lowered metabolic state, which mitochondrial activity...

Valosin-containing protein (VCP) is a highly conserved molecular chaperone that regulates a wide array of essential cellular processes. Mutations in VCP are causative of degenerative disease that can affect muscle, brain and bone. Despite VCP being implicated in many major pathways in the cell, the mechanism of disease pathogenesis is unknown. To gain insight into the degeneration associated wi...

PURPOSE To discuss computed tomography (CT) evaluation of the etiology of vocal cord paralysis (VCP) due to thoracic diseases. MATERIALS AND METHODS From records from the past 10 years at our hospital, we retrospectively reviewed 115 cases of VCP that were evaluated with CT. Of these 115 cases, 36 patients (23 M, 13 F) had VCP due to a condition within the thoracic cavity. From these cases, w...

Dominant mutations in the valosin-containing protein (VCP) gene cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia, which is characterized by progressive muscle weakness, dysfunction in bone remodeling, and frontotemporal dementia. More recently, VCP has been linked to 2% of familial amyotrophic lateral sclerosis cases. VCP plays a significant role i...

helicopter-borne electromagnetic (hem) is a fast and high resolution airborne electromagnetic (aem) method that is frequently used for imaging of the subsurface resistivity structures. this is a versatile and cost effective method, frequently has used in mineral and groundwater exploration and various environmental problems. modern frequency-domain hem systems utilize small electromagnetic, mag...

Valosin-containing protein (VCP) is a homohexameric ATPase involved in a multitude cellular processes and it was recently shown that VCP is trimethylated at lysine 315 by the VCP lysine methyltransferase (VCPKMT). Here, we generated and validated a constitutive knockout mouse by targeting exon 1-4 of the Vcpkmt gene. We show that Vcpkmt is ubiquitously expressed in all tissues examined and conf...

PURPOSE Valosin-containing protein (VCP) has been shown to be associated with metastasis and prognosis in human cancers. In the present study, the correlation of VCP with recurrence and prognosis in patients with prostate cancer (PCA) receiving conservative therapy was examined. EXPERIMENTAL DESIGN VCP expression was analyzed immunohistochemically in 136 patients ranging from 46 to 92 years (...

Web 2.0 sociable technologies (such as social network sites, SNS) create new online interpersonal collaboration and communication. Particularly, given the proliferation of virtual community page (VCP, ex. Facebook fan page and group) participation, the sustainability of VCP has been recognized as a critical issue. While existing studies have started to address this issue through classical indiv...