the surviving 4741 patients, 89 reports were followed up with ophthalmologists. The ophthalmologists consider that 30 (83%) of the 36 cases for which there is objective evidence of visual field defect are probably or possibly related to vigabatrin. In four cases they did not know whether the defect was related to vigabatrin treatment, and in the remaining two cases the defect was considered not...

In light of theirclosely related mechanisms of action, and preliminary clinical evidence suggesting that they possess similar efficacies, it has been anecdotally suggested that vigabatrin and tiagabine may prove to be therapeutically indistinguishable. As a result, we have conducted a preclinical comparison of their anticonvulsant profile and mechanism of action. Pentylenetetrazol and maximal e...

OBJECTIVE Approximately one-third of all children with epilepsy do not achieve complete seizure improvement. This study evaluated the efficacy of Vigabatrin in children with intractable epilepsy. METHODS From November 2011 to October 2012, 73 children with refractory epilepsy (failure of seizure control with the use of two or more anticonvulsant drugs) who were referred to the Children's Medi...

Three new antiepileptic drugs (AEDs) are finding increasing use in medical practice. To examine their efficacy and side-effect profile, 483 patients with epilepsy attending either a specialized epilepsy clinic or general neurology clinic under the care of a single consultant neurologist were reviewed. Of these patients 127 had received lamotrigine, 100 vigabatrin and 27 gabapentin. In all but t...

Recent findings in mice with targeted deletion of the GABA-metabolic enzyme succinic semialdehyde dehydrogenase revealed a new role for supraphysiological GABA (4-aminobutyric acid) in the activation of the mechanistic target of rapamycin (mTOR) that results in disruption of endogenous mitophagy. Employing biochemical and electron microscopic methodology, we examined the hypothesis that similar...

Vigabatrin use in some epilepsy patients has been associated with persistent visual field constriction and retinal dysfunction. The mechanism is unknown, but could be related to vigabatrin, chronic epilepsy, GABA toxicity, or the effect of a metabolite in combination with a predisposing genotype. The aim of this study was to investigate the latter two hypotheses. Levels of brain gamma-aminobuty...

Five antiepileptic drugs have been marketed in the last decade. We report here a retrospective study of patients attending our unit who were prescribed one of the new antiepileptic drugs. All these patients had refractory localization related epilepsy and had failed to respond to a first-line drug. The drugs had a different profile of side-effects but topiramate (42%) was the most common drug t...

A validated, selective, and sensitive chromatographic method for determination of two antiepileptic drugs, vigabatrin (VGA) and gabapentin (GBA) has been developed. Determination was obtained by pre-column reaction of the samples with fluorescamine and separating the corresponding derivatives with a reverse phase HPLC on a 5 micro ASMT BANsil CN column and fluorescence detection (lex 390 nm, le...

Introduction. Gabapentin is a recently introduced antiepileptic drug [l]. Gabapentin is now widely prescribed for the management of neuropathic pain [2]. Designed to mimic GABA, its mechanism c! action remains elusive [3]. Daily use of gabapentin is associated with above normal occipital lobe GABA in those patients whose seizure control improved [4, 51. Vigabatrin is one of the most potent of t...