Vinflunine is a novel fluorinated Vinca alkaloid currently in Phase II clinical trials, which in preclinical studies exhibited superior antitumor activity to that of two clinically useful Vinca alkaloids, vinorelbine and vinblastine. All three of the drugs block mitosis at the metaphase/anaphase transition, leading to apoptosis. The mechanism of the mitotic block is not known. On the basis of r...

lesser periwinkle (vinca minor l.), a member of apocynaceae, is not only an ornamental plant with lilac-blue flowers, but also a medical plant producing an important alkaloid, vincamine, found in the leaves which shows a pronounced cerebrovasodilatory and neuroprotective activity. this plant is native to northern spain, western france, central and southern europe, and caucasus. it has been rece...

periwinkle (vinca minor l.) is an evergreen perennial herbaceous plant that belongs to the family apocynaceae. the aerial part of this plant contains certain alkaloids such as vincamine, isovincamine and vincine. the most important of these is vincamine that re-duces blood pressure and promotes memory and the ability for mental concentration. mi-cropropagation could be a good alternative for th...

Vinca rosea (fam. apocynaeceae) is a medicinal plant commonly grown in Indian gardens and a native of West Indies. Various parts of this plant have been reported to exert antidiabetic, hypotensive and antileukemic property (1-3). Significant hypoglycemic and antihyperglycemic activity of water soluble fraction of alcoholic extract of leaves of Vinca rosea in rats have already been reported by t...

Sergey V. Dmitriev, Avinash Khare, Panayotis G. Kevrekidis, Avadh Saxena and Ljupćo Hadžievski Institute for Metals Superplasticity Problems RAS, 39 Khalturina, Ufa 450001, Russia Institute of Physics, Bhubaneswar, Orissa 751005, India 3 Department of Mathematics and Statistics, University of Massachusetts, Amherst, MA 01003-4515, USA Center for Nonlinear Studies and Theoretical Division, Los A...

Cucumber mosaic virus (CMV) is a cosmopolitan virus which may also have small satellite RNAs (satRNA) associated with it affecting symptom development. Vinca minor (periwinkle) plants exhibiting subtle mosaic symptoms tested positive for CMV by enzyme linked immunosorbent assay (ELISA). Double-stranded ribonucleic acid (dsRNA) analysis of CMV-Vinca field isolates in Nicotiana tabacum ‘Glurk’ su...