Developing new methods for chemotherapy drug delivery has become a topic of great concern. Vinca alkaloids are among the most widely used chemotherapy reagents for tumor therapy; however, their side effects are particularly problematic for many medical doctors. To reduce the toxicity and enhance the therapeutic efficiency of vinca alkaloids, many researchers have developed strategies such as us...

A survey of isolated thylakoids from 11 different higher plant species (Spinacia oleracea L., Pisum sativum L., Vicia faba L., Brassica napus L., Vigna sinensis L., Vinca minor L., Secale cereale L., Triticum aestivum L., Triticosecale Wittn., Hordeum vulgare L., Zea mays L.) indicated that the ratio of the oligomeric:monomeric form of the light-harvesting complex II was twofold higher for the ...

Cancer is deadliest disease ever known. Vinca extract has the potential and beneficial in treating various cancer conditions. However, till date no known syrup of plant or its been formulated. a debilitated condition formulation evaluation herbal alcoholic vinca may serve patient compliance ease administration by oral route. The was formulated using Vinca. Syrups are easy to formulate help over...

The role of oxidative stress is known among the patients diabetes as level reactive oxygen species was high diabetic patients. This generated in due to continuous glucose levels that cause decrease defence mechanism for antioxidant enzymes within body. reduction leads towards generation hydroxyl radicals consequently results lipid peroxidation. objective this study examine efficacy Vincamine ex...

A comparative study of the loading and retention properties of three structurally very closely related vinca alkaloids (vincristine, vinorelbine and vinblastine) in liposomal formulations has been performed. All three vinca alkaloids showed high levels of encapsulation when accumulated into egg sphingomyelin/cholesterol vesicles in response to a transmembrane pH gradient generated by the use of...

Aberrant expression of B-tubulin isotypes is frequently described in tumor tissues and tubulin-binding agent (TBA)–resistant cell lines. There is limited understanding of the role of specific B-tubulin isotypes in cellular sensitivity to TBAs, and to gain insights into the functional role of BIIand BIVb-tubulin, we examined these isotypes in lung cancer cell lines NCI-H460 (H460) and Calu-6. Dr...