Objective: Considering the emergence of biofilm-associated pathogens with multidrug resistance, the objective(s) of the present study was to evaluate the anti-virulence property of Syzygium aromaticum extracts/fractions against 2 multidrug-resistant catheter isolates. Materials and Methods: Pulverized clove buds were subjected to bioactivity-guided isolation to identify the bioactive extract/fr...

Objective(s): Honey’s ability to kill microorganisms and even eradication of chronic infections with drug-resistant pathogens has been documented by numerous studies. The present study is focused on the action of honey in its sub-inhibitory levels to impact on the pathogens coordinated behaviors rather than killing them. Materials and Methods:</strong...

backgrounds and aims: mastitis is a mammalian disease which is considered important due to its potential economic damages. trueperella pyogenesis is one of the important opportunistic pathogens of the mammary glands of cattle. this bacterium can produce acute mastitis infection in dairy cattle. in fact, this bacterium has several virulence genes which contribute to its pathogenicity. therefore,...

Five previously analyzed white spot syndrome virus (WSSV) strains from northwest Mexico, differing in their genome architecture as well virulence, were selected (high virulence JP and LG strains; moderate GVE DIV low LC10 strain) to evaluate pathogenesis response vitro. Expression of phagocytosis-activating protein PAP, manganese superoxide dismutase MnSOD peroxiredoxin PRX, two genes immediate...

Abstract Enteropathogenic E. coli (ETEC) is a common infection in neonatal and nursery pigs resulting significant economic losses from morbidity, mortality, production inefficiencies. Due to the plasticity of its genome, can be particularly challenging manage swine systems. Populations are continuously changing their genome content via multiple methods genomic modification better adapt compete ...

The emergence of antibiotic-resistant bacteria and hospital-acquired bacterial infection has become rampant due to antibiotic overuse. Virulence factors are secondary growth important in their pathogenesis, therefore, new antimicrobial therapies inhibit virulence becoming strategies against resistance. Here, we focus on anti-virulence that act through anti-quorum sensing the subsequent clearanc...

Context: The unprecedented rise in antibiotic-resistant bacterial infections is a challenging dilemma, urging the development of novel and effective antibiotics for treatment such infections. Anti-virulence therapy promising solution this regard. Unlike antibiotics, these drugs could lower selective evolutionary pressure on population target virulence factor rather than growth pathways, thereby...