The increased awareness of antiviral resistance over the past decade has paralleled the development of new antiviral agents. While such resistant viral isolates are of clinical significance primarily in immunocompromised individuals, the development and transmission of such mutants have been reported in immunocompetent persons as well. As antiviral agents are increasingly utilised by the clinic...

Tomato yellow leaf curl virus (TYLCV) is a major tomato virus in tropical and subtropical regions. In this study, 134 accessions of Solanum lycopersicum and six accessions of Solanum peruvianum were assessed for resistance to an Iranian isolate of TYLCV. Plants were inoculated using whiteflies (Bemisia tabaci) and the reaction of plants was evaluated based on either disease symptoms or viral DN...

Mice allografted with different sarcomas, induced by the Schmidt-Ruppin variant of Rous sarcoma virus (RSV-SR), showed a resistance against subsequent isografting of 9 different Rous sarcomas. Transplantation resistance could also be induced by Rous mouse tumor cells x-irradiated with 8000 r or with cell-free tumor extracts, containing no demonstrable virus. No transplantation resistance could ...

Despite the success of potent combination therapy against HIV, a large proportion of patients experiences treatment failure. Due to the high degree of plasticity of the HIV genome, ongoing virus replication in the presence of drug pressure will result in the selection of virus mutants with reduced drug susceptibility. As a result, antiretroviral drug-resistance is a common denominator in treatm...

The DBA/2 mouse Rmcf gene is responsible for in vivo and in vitro resistance to infection by the polytropic mink cell focus-forming (MCF) virus subgroup of murine leukemia viruses (MLVs). Previous studies suggested that Rmcf resistance is mediated by expression of an interfering MCF MLV envelope (Env) gene. To characterize this env gene, we examined resistance in crosses between Rmcf(r) DBA/2 m...

methods and materials: hepatitis b virus dna was detected by conventional pcr in some of the serum samples obtained from hbsag-positive chronic hepatitis b (chb) patients who were referred to health centers of shahrekord for routine monitoring of the disease. subsequently, using real-time pcr, the dna samples were used for genotyping and analysis of resistance to lamivudine. results: the dna wa...

The effect of VSV infection in rabbit eye was investigated. The findings indicated that maximum virus growth in the rabbit cornea coincided with peak keratitis on postinfection day 1. Thereafter, keratitis was generally not observed, whereas infectious virus was detected in the cornea through day 6. Primary virus infection in the cornea of one eye produced serum-neutralizing antibody which did ...

Variability in the cultivated germplasm for economic traits such as resistance to rice tungro virus, sheathblight, yellow stem borer, drought and salt tolerance is limited. This necessitated search for the genes in secondary and tertiary gene pool of genus Oryza. Fortunately, wild species are an important reservoir ofuseful genes for resistance to major disease, pest and tolerance t...

Avian lymphoid leukosis can be induced by lymphoid leukosis viruses belonging to Subgroups A, B, C, and D. The endogenous virus of the chicken (Rous-associated virus type 0) belongs to Subgroup E and has little, if any, potential for inducing lymphoid leukosis. Nearly all chicken flocks are infected with Subgroup A lymphoid leukosis virus. This virus can be transmitted from dam to offspring or ...

RPE.40 is a strain of mutated CHO-K1 cells with elevated resistance to Pseudomonas exotoxin A, Sindbis virus, and Newcastle disease virus. Virus resistance is due to an inability to cleave precursor viral membrane glycoproteins and produce infectious virions. Transfection of RPE.40 cells with cDNA for mouse furin causes them to lose all resistance and become as sensitive as wild-type cells to t...