PURPOSE The study on the interaction between small molecules and DNA has been very useful for investigating the structure and physical properties of DNA, elucidating the damage mechanism of DNA and significant in the design of new drugs targeted to DNA. This article describes an interaction of native calf thymus DNA (ctDNA) with a new 3, 4-dihydropyrano[c]chromene derivative, 2-amino-4-(4- chlo...

The colloidal stability and thermoresponsive behavior of poly(N-isopropylacrylamide) brushes grafted from cellulose nanocrystals (CNCs) of varying graft densities and molecular weights was investigated. Indication of the grafted polymer brushes was obtained after AFM imaging of CNCs adsorbed on silica. Also, aggregation of the nanoparticles carrying grafts of high degree of polymerization was o...

BACKGROUND Chondramides are cyclodepsipeptides produced by strains of the myxobacterium, Chondromyces crocatus. These peptides, which have been reported to inhibit yeast and mammalian cell proliferation, are related to jasplakinolide, which has been isolated from marine sponges of the genus Jaspis and has been shown to interfere with the actin cytoskeleton (a structural component of cells that ...

The key in selective laser sintering (SLS) of polyamide 12 for exceeding the cusp from a prototyping to a serial production technique poses the long-term behavior of such components. The improvement of additive manufacturing technologies is attended by the enlargement of the possible ranges of use. The crucial obstacle for their actual use is the ignorance of the long-term properties and the co...

BACKGROUND/AIMS Increased viscosity and supersaturation of cholesterol in gallbladder bile, as well as an impaired motility of the gallbladder, are considered to be important factors in the pathogenesis of cholesterol gallstones. However, the relation of these parameters has not yet been determined. MATERIAL AND METHODS Bile viscosity (mPa s) was measured by rotation viscosimetry and the comp...

The use of plastic much films has been fundamental to promoting food production in many regions the world. However, concern is growing about progressive accumulation residues soil after crop harvest and its subsequent impact on health potential enter chain. Although biodegradable have developed prevent these problems, it still unclear whether they are environmentally benign. Here we evaluated p...

Efeitos de adição de sal, concentração, presença de contraíons, temperatura e agente quelante em soluções aquosas de pectina, alginato de sódio e misturas destes foram analisadas por viscosimetria e espalhamento de luz dinâmico (DLS). A viscosidade intrínseca dos sistemas binários diminuiu com a adição de sal e com o aumento da temperatura, porém, mostrou-se insensível à adição de NaEDTA. Como ...

Various thermally responsive block and graft copolymers based on poly(Nisopropylacrylamide) (PNIPA) have been synthesised. Poly(ethyleneoxides) (PEO) with different chain lengths were used as hydrophilic blocks and grafts. The graft copolymers were synthesised in two steps. Firstly, two functional copolymers were prepared by free radical polymerisation of N-isopropylacrylamide (NIPA) with eithe...

Until now, transformation with linear DNA has not been demonstrated in Streptomycetes, although it has been established in a thermophilic Actinomyces species, Thermoactinomyces vulgaris (Hopwood & Wright, 1972). The main tool used in Streptomycete genetics is conjugation (Hopwood, 1967). In the wake of a genetic map for Streptomyces coelicolor, maps for other strains were constructed by means o...

A novel method of calibrating size exclusion chromatography (SEC or known as GPC) and dynamic light scattering (DLS or known as QELS or PCS) is proposed for the characterization of gelatin. A conventional calibration of SEC or DLS normally requires a set of narrowly distributed gelatin standards with different molecular weights. By contrast, the new method uses only one broadly distributed gela...