Vitamin D deficiency appears to be an underestimated risk factor for cardiovascular disease in patients with chronic kidney disease. Evidence from both basic science and clinical studies supports the possible protective role of vitamin D beyond its effect on mineral metabolism. Toxicity of pharmacologic doses of active vitamin D metabolites, in particular calcitriol, is mainly due to the possib...

background: the role of oxidative stress in endosulfan-induced reproductive toxicity has been implicated. this study was performed to evaluate the possible protective effect of vitamins e and c, against endosulfan-induced reproductive toxicity in rats. methods: fifty adult male sprague–dawley rats were randomly divided into five groups (n=10 each). the groups included a control receiving vehicl...

the aim of this study was to examine the adverse effects of zinc nanoparticles on hematological indices of trout and investigate the improvement of these indices after vitamin c treatments. this study assesses the protective role of vitamin c in fish exposed to zno nps. two concentrations of zno-nps (40 and 80 mg l-1) and two doses of vitamin c (400 and 800 mg per kg of feed) were used to treat...

INTRODUCTION Vitamin D is increasingly recognized to have several beneficial effects. Vitamin D deficiency is widely prevalent. Physicians often treat patients with high doses of vitamin D for various ailments without any monitoring for adverse effects and the prescribed doses often far exceed requirements resulting in toxicity. We present here a classic case of iatrogenic hypervitaminosis D, w...

A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBP's biological functions in vitamin D metabolism and action. On vitamin D-replete diets, DBP-/- mice had low levels of total serum vitamin D metabolites but were otherwise normal. When maintained on vitamin D-deficient diets for a brief period, the DBP-/-, but...

This case report presents fluoconazole efficacy to reduce hypercalcaemia and increased urinary calcium excretion in a patient with nephrocalcinosis after a long history of recurrent renal stones caused by a loss-of-function mutation of the CYP24A1 gene. The CYP24A1 gene codes for a key enzyme in the vitamin D endocrine system that protects against vitamin D toxicity by degrading the circulating...

and Invited Presentation: Dec 2013 American Association for Cancer Research (AACR)The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, Atlanta, GA.“Vitamin D and prostate Cancer in African-American Men” Abstract and Poster presentation: November 2015 Steroid Research Congress Chicago. “Vitamin D metabolites in prostate tissue and serum from African...

Vitamin D is important for the development, growth, and mineralization of the skeletal in neonates and children. Vitamin D is essential for intestinal absorption of calcium. Vitamin D is metabolized to 25-hydroxyvitamin D and then to 1,25-dihydroxyvitamin D. Pregnant women in developed countries often have insufficient serum concentrations of 25-hydroxyvitamin D and a supplementation of vitamin...

For adults, the 5-microg (200 IU) vitamin D recommended dietary allowance may prevent osteomalacia in the absence of sunlight, but more is needed to help prevent osteoporosis and secondary hyperparathyroidism. Other benefits of vitamin D supplementation are implicated epidemiologically: prevention of some cancers, osteoarthritis progression, multiple sclerosis, and hypertension. Total-body sun ...