Postreplicative mismatch repair plays a major role in mediating the cytotoxicity of agents generating O6-methylguanine in DNA. We previously showed that a methylating antitumor triazene compound, temozolomide, induces apoptosis and that the persistence of O6-methylguanine in DNA is required to trigger the process. We wanted to test whether the latter apoptotic signal is dependent on a functiona...

Lithium, besides mood stabilization, might be involved in neuroprotection. Previously we have found that the treatment with lithium increased the levels of p21(WAF/Cip1 and survivin in human glioblastoma A1235 cells. The aim of the present study was to examine the cytotoxic effect of glutamate on these cells, and to determine whether lithium can protect A1235 cells against toxic effects of glut...

The paper describes an algorithm for constructing convective weather avoidance polygons. The algorithm combines weather avoidance fields (WAF) from the en route convective weather avoidance model (CWAM) with edges automatically detected in the echo tops field, clustering, convex hull fitting and wind data to build weather avoidance polygons. Results for 2 case days with significantly different ...

Copepods play a critical role in the marine food webs, being source for organisms. In this study, we investigated toxic effects of Water Accommodated Fractions (WAFs) from three types oil: Naphthenic North Sea crude oil (NNS), Intermediate Fuel Oil (IFO 180) and commercial Marine Gas (MGO). The WAFs were prepared at 10 °C 30 PSU (practical salinity unit), tested on copepod Acartia tonsa differe...

The performance and lifespan of a solid-state drive (SSD) depend not only on the current input workload but also on its internal media fragmentation formed over time, as stale data are spread over a wide range of physical space in an SSD. The recently proposed streams gives a means for the host system to control how data are placed on the physical media (abstracted by a stream) and effectively ...

Our system to Micro-blog Track at TREC2011 is described in this paper, which includes data obtaining and preprocessing, index building and query expansion. There‟re two methods of query expansion introduced in this report: Word Activation Force algorithm (WAF) and Electric Resistance Network. We also show the evaluation results for our team and the comparison with the best and median evaluations.

This paper examines the effects and potential benefits of utilising Web Application Firewalls (WAFs) and database proxies in SQL injection testing of web applications and services. We propose testing the WAF itself to refine and evaluate its security rules and prioritise fixing vulnerabilities that are not protected by the WAF. We also propose using database proxies as oracles for black-box sec...

Ambient PM2.5 exerts strong regional pattern for its ability long-range transport, implying that including the features of surrounding stations may improve accuracy machine-learning based model to estimate surface from satellite-retrieved aerosol optical depth (AOD). However, most current models either just use single point features, or simply average observed adjacent on a fixed spatial propor...

This paper deals with fuzzy logic controllers. Our interest is in studying different techniques of defuzzification methods. In particular, we propose a generalization the WABL method to multiple output system controller. We give numerical realization, and show advantages this compared other methods (MOM, COG, WAF,\ldots) through an application for intelligent control air conditioners.