We used continuous flow micro-devices as bioreactors for the production of a glycosylated pharmaceutical product (a monoclonal antibody). We cultured CHO cells on the surface of PMMA/PDMS micro-channels that had been textured by micromachining and coated with fibronectin. Three different micro-channel geometries (a wavy channel, a zigzag channel, and a series of donut-shape reservoirs) were tes...

Hydrodynamic forces in bioreactors can decisively influence extracellular matrix deposition in engineered cartilage constructs. In the present study, the reduced fluid shear, high-axial mixing environment provided by a wavy-walled bioreactor was exploited in the cultivation of cartilage constructs using polyglycolic acid scaffolds seeded with bovine articular chondrocytes. Increased growth as d...

In recent years, the lattice Boltzmann equation has developed into a promising technique for computational fluid dynamics (CFD). The model (LBM) approach is derived from and kinetic theory, as opposed to standard CFD methods that are based on direct discretization of Navier–Stokes equations. this paper, Newtonian flow passing through wavy walled channel been examined laminar turbulent transitio...

This study explores the mechanism of flow boiling critical heat flux (CHF) for FC-72 in a 2.5 mm 5 mm vertical upflow channel that is heated along its 2.5 mm sidewall downstream of an adiabatic development section. Unlike most prior CHF studies, where the working fluid enters the channel in liquid state, the present study concerns saturated inlet conditions with finite vapor void. Temperature m...

Article history: Received 13 June 2016 Accepted 14 July 2016 Available online 19 July 2016 The present article addresses the effects of convective heat transfer of nanofluid utilizing Buongiorno'smodel in a wavy channel. The simultaneous effects of Brownianmotion and thermophoresis are discussed. The solutions for velocity, temperature and concentration are analytically obtained. Effects of sun...