Genistein derivatives were synthesized from genistein through a facile sonochemical approach in high yields. The bioassay was performed on ovariectomized (OVX) rats in terms of bone mineral density (BMD) and the weight of bone ash (WBA) to lead to the discovery of eight novel genistein-based selective estrogen receptor modulators. Attention to the structure-activity relationship disclosed that ...

Currently, the best performing models for Chinese word segmentation (CWS) are extremely resource intensive in terms of annotation data quantity. One promising solution to minimize the cost of data acquisition is active learning, which aims to actively select the most useful instances to annotate for learning. Active learning on CWS, however, remains challenging due to its inherent nature. In th...

Sommario In questo lavoro viene proposto un agente intelligente denominato DL-WBA (Description Logic based Web Browsing Assistant Agent) per supportare un utente nelle sue attività di browsing sul Web. L’attività di ricerca di nuove sorgenti informative è basata sull’utilizzo di un profilo utente che registra gli interessi e le preferenze dell’utente. Ogniqualvolta l’utente effettua una query, ...

Understanding current environmental conditions is essential for autonomous ships, among which real-time estimation of sea a key aspect. Considering the ship as large wave buoy, state can be estimated from motion responses without extra sensors installed. This task challenging since relationship between and hard to model. Existing methods include buoy analogy (WBA) method, assumes linearity moti...

Renewables-based power grid expansion has increased the use of wood biomass as a low-carbon fuel, resulting in generation predominantly inorganic ash (WBA) waste during combustion. The conservation historically valuable, damaged, and energy-inefficient buildings can help downsize carbon emissions energy consumption, while promoting alternative repair materials, including unavailing materials su...

BACKGROUND Interferon-gamma (IFN-gamma) ELISPOT assays incorporating Mycobacterium tuberculosis-specific antigens are useful in the diagnosis of tuberculosis (TB) or latent infection. However, their utility in patients with advanced HIV is unknown. We studied determinants of ELISPOT responses among patients with advanced HIV infection (but without active TB) living in a South African community ...

BACKGROUND Leprosy is a chronic infectious disease caused by Mycobacterium leprae that can manifest a wide variety of immunological and clinical outcomes ranging from potent humoral responses among borderline lepromatous (BL) and lepromatous (LL) patients to strong cellular responses among tuberculoid (TT) and borderline tuberculoid (BT) patients. Until recently, relatively little has been know...

Intramammary infusion of the antigen used to sensitize cows by the systemic route induces a local inflammation associated with neutrophil recruitment. We hypothesize that this form of delayed type hypersensitivity, which may occur naturally during infections or could be induced intentionally by vaccination, can impact the outcome of mammary gland infections. We immunized cows with ovalbumin to ...

Little is known about the functional and neural architecture of social reasoning, one major obstacle being that we crucially lack the relevant tools to test potentially different social reasoning components. In the case of belief reasoning, previous studies have tried to separate the processes involved in belief reasoning per se from those involved in the processing of the high incidental deman...

UNLABELLED The objective of this study was to evaluate the in vivo assay of folate receptors in nonfunctional pituitary adenomas using preoperative (99m)Tc-folate SPECT/CT and Western blot analysis (WBA) of surgical specimens as the standard. METHODS Fifty-six patients (29 men, 27 women; age range, 29-82 y) with clinically nonfunctional pituitary adenomas on MRI underwent preoperative imaging...