PURPOSE To evaluate the possible changes in CYP2E1 expression and activity in hyperlipidemia (HL), we evaluated the pharmacokinetics of chlorzoxazone (CZX) as a CYP2E1 probe in rats with HL induced by poloxamer 407 (HL rats). METHODS The pharmacokinetics of CZX and its 6-hydroxy metabolite (OH-CZX) were evaluated after intravenous administration of 20 mg/kg CZX to both control and HL rats. We...

A Boolean circuit C on n inputs x1, . . . , xn is a directed acyclic graph (DAG) with n nodes of in-degree 0 (the inputs x1, . . . , xn), one node of out-degree 0 (the output), and every node of the graph except the input nodes is labeled by AND, OR, or NOT; it has in-degree 2 (for AND and OR), or 1 (for NOT). The Boolean circuit C computes a Boolean function f(x1, . . . , xn) in the obvious wa...

The lack of readily available experimental systems has limited knowledge pertaining to the development of Salmonella-induced gastroenteritis and diarrheal disease in humans. We used a novel low-shear stress cell culture system developed at the National Aeronautics and Space Administration in conjunction with cultivation of three-dimensional (3-D) aggregates of human intestinal tissue to study t...

Chronic administration of the poloxamer 407 (P-407), a block copolymer, to elevate serum lipids in mice is a well-established mouse model of hyperlipidemia and atherosclerosis. We tested the hypothesis that the activity of several types of proteases in heart and liver tissue is changed in the early stages of atherosclerosis development. Additionally, we evaluated whether increased serum lipids ...

The objective of this study was to determine the effect of spineless cactus incorporation in food of dairy goats and growing kids on milk production and composition and on kid's growth and meat characteristics. Two experiments were conducted on Tunisian local goats. In the first, 30 females were divided into two groups; goats of Control group were reared on grazing pasture receiving indoor 0.5 ...

Study protocols for the characterization of endocrine active compounds presented in Workshop 4 included the enhanced Organization for Economic Cooperation and Development (OECD) test guideline (TG) 407, the medium-term rat liver and rat multi-organ carcinogenicity assays, and an enhanced one-generation reproduction study. The outcome of rat studies on flutamide and ethinylestradiol indicated th...

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

This work deals with the measurement of radioactivity concentrations from different cement samples collected South Gondar Zone, Ethiopia. The naturally occurring radioisotopes and radiation health impact indices caused by these nuclides in are indisputable dwellings. Specifically, average for 226 Ra, 232 Th 40 K were estimated as 76.53, 81.67, 407 Bq kg −1 , respectively. It was seen that all m...