Evaluation of testicular toxicity during drug development is currently based on histopathological evaluation. A sensitive biomarker for testicular toxicology could provide an in-life and "early warning" measurement. Previous studies suggested that disruption of spermatogenesis induced leakage of germ cell proteins from seminiferous tubules (STs) into interstitial fluid (IF); such proteins have ...

The western is the only fully-fledged film genre defined by geographical location. Yet does this mean that place, or a sense of place, plays a more significant role in the Western than in other film genres? On the face of it, it would seem that it does not. For the most part, place typically appears in the Western as little more than the scenic background to the action that is the real thread o...

Microfluidic methods for cellular studies can significantly reduce costs due to reduced reagent and biological specimen requirements compared with many traditional culture techniques. However, current types of readouts are limited and this lack of suitable readouts for microfluidic cultures has significantly hindered the application of microfluidics for cell-based assays. The In-Cell Western (I...

The stigmatization of Islam with Islamophobia in Indonesia leads to a formless war that makes <em>jihad</em> struggles under the Qur’an and Hadith “sacred canopy theory” approach. interpretation words <em>shahid</em>, <em>jihad</em>, <em>qital</em> turned into holy warrior who was then suggested as terrorists. This research is based on literature ...

High Noon (1952) was a landmark artifact of American popular political culture of the high Cold War. Screenwriter Carl Foreman intended it as a commentary on Hollywood capitulation to HUAC. Director Fred Zinneman and star Gary Cooper saw it as a film about the nobility of the individual in the face of a failure of public morality. John Wayne, the film star and conservative archetype of the peri...

Technological advances now allow us to rapidly produce CARs and other antibody-derived therapeutics targeting cell surface receptors. To maximize the potential of these new technologies, relevant extracellular targets must be identified. The Pediatric Oncology Branch of the NCI curates a freely accessible database of gene expression data for both pediatric cancers and normal tissues, through wh...

BACKGROUND As a more detailed picture of nervous system function emerges, diversity of astrocyte function becomes more widely appreciated. While it has been shown that cocaine experience impairs astroglial glutamate uptake and release in the nucleus accumbens (NAc), few studies have explored effects of self-administration on the structure and physiology of astrocytes. We investigated the effect...

INTRODUCTION Reduced vascular compliance in patients with hypertension results from an increase in extra-cellular matrix (ECM) protein deposition in blood vessels. At least two key factors, namely mechanical strain and neurohumoral mediators, for example Angiotensin II (Ang II), promote fibrogenesis within vessel walls; however potential interactions between these have not been clearly defined....