The aim of the work was to develop Theophylline hydrochloride sustain release tablet using Methocel k 15 MCR, Methocel K100M CR premium and Methocel K4M CR premium in blending and granulation stage of processing and evaluate their physico-chemical properties and also compared the dissolution profile with the marketed drugs.Tablets were prepared by wet granulation method. The active ingredient, ...

The study investigates ibuprofen with wax-like properties as a multifunctional agent (as an active component and as a melt binder). Binding efficiency was compared with granules prepared by wet granulation using polyvinylpyrollidone (PVP K-30) as a binder for micromeritic, physical and mechanical properties such as angle of repose, particle size distribution Carr's index, Hausner's ratio, crush...

Aim: The objective of this work was to study the effects of formulation variables on the release kinetics of paracetamol tablet formulation. Materials and Methods: Paracetamol tablets were formulated using wet granulation (WG) and direct compression (DC) using two predetermined pressures. Avicel, dicalcium phosphate (DCP) and pregelatinized starch (PGS) were used as directly compressible...

The drug making resreach has accentuated on extrusion technology for a long time. The advance of drug bioavailibility, bead manufacturing and granulation is assured by extrusion procedures. There are also diverse effects in resereches with respect to the use of process understanging as a tool in quality management. Many initiatives of FDA such as PAT and QBD are getting accepted. In this survey...

Ethanolic extract of leaves of O. sanctum was investigated for normal wound healing and dexamethasone depressed healing using incision, excision and dead space wound models in albino rats. The extract of O. sanctum significantly increased the wound breaking strength in incision wound model. The extract treated wounds were found to epithelialize faster and the rate of wound contraction was signi...

Aim. To develop the composition and technology for obtaining combined drug of indapamide with enalapril prolonged action. Materials methods. Indapamide maleate substances as active components, polyvinylpyrrolidone, calcium stearate, lactose monohydrate, hydroxypropyl methylcellulose excipients were used. The pharmaco-technological studies conducted according to methods State Pharmacopoeia Ukrai...

This paper presents the interaction system within mechanical soil processing process, consisting of two large elements, metal tool and soil. Due to main forces acting on chisel knives—friction impact with sandy soil—the wear these knives was determined. To determine wear, a stand used which allowed testing chisel-type in laboratory conditions by changing their functional parameters: working dep...

Health technology The study evaluated tympanomastoid surgery. A comparator was not explicitly stated at the outset, although it was likely to be no tympanomastoid surgery. The health technology was compared between two different patient groups. These were patients with wet ear suffering from chronic suppurative otitis media (CSOM) and patients with dry ear suffering from CSOM. The wet-ear group...

Breakthrough energy savings were recently projected by a spray-dryer free dairy powder manufacturing process based on superconcentration and granulation. The extent of the recirculation rate for granulation, determines performance. In this study, evolution physical properties during granulation was investigated model system (skim milk microfiltrate) using rheological shear-cell techniques. Resu...