Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a therapeutic agent has been access to sufficient amounts of material for biological testing. Although there are two reported syntheses of neo, bot...

Antihemorroidal hubber Leuco hubber Panotile Bacisporín Linitul antibiótico Poly-pred Bexicortil Liquipom dexa-antibiótico Pomada antibiótica liade Bio-hubber/fuerte Maxitrol Positon crema Blastoestimulina óvulos Neo-analsona Positon crema Blastoestimulina pomada Neo-bacitrin Potison loción Creanolona Neo-bacitrin hidrocortisona Positon ungüento Decadran neomicina Neo-hubber Rinobanedif Deltaci...

To determine if expression of mutant p21 ras could convert Simian Virus 40-immortalized human uroepithelial cell line (SV-HUC) to tumorigenicity, SV-HUC cells were transfected with pSV2-neo (a neomycin-resistant gene) or PREJ/ras (c-HA-ras-1 with the 12th codon mutation and neo). Seven independent G418-resistant clones (A----G) were isolated from each group (SV-HUC/ras and SV-HUC/neo). SV-HUC/r...

Die Anwendung Remote Task Control entstand in Zusammenarbeit der Firmen HORSCH und geo-konzept im Forschungsprojekt Geo Farm und ermöglicht eine durchgängig automatisierte Prozesskette von der Bereitstellung und Archivierung georeferenzierter Applikationskarten und Datenübertragung zur Landmaschine bis zur Ausführung und Dokumentation des variablen Applikationsprozesses im Feld. Das Projekt Geo...

objectives: multiple sclerosis is an incurable and chronic disease of the central nervous system. the main purpose of this survey is to compare the character types and life expectancy of patients suffering from m. s as compared with normal people. this survey was conducted using the persian translation of neo-ffi (neo-five factor inventory) and herth life expectancy. methods:thirty nine people ...

To test the hypothesis that personality structure differs across levels of cognitive ability, personality traits of 154 participants of various ages and educational backgrounds were rated by themselves and two well-informed judges using the Estonian Personality Item Pool NEO (EPIP-NEO; Mõttus, Pullmann, & Allik, 2006). When participants were divided into two groups on the basis of their ability...

In most phylogenetic lineages, the evolution of sex chromosomes is accompanied by their heteromorphization and degradation of one of them. The neo-sex chromosomes are useful model for studying early stages of these processes. Recently two lineages of the neo-sex chromosomes on different stages of heteromorphization was discovered in Pamphagidae family. The neo-sex chromosome heteromorphization ...

The present study employed multivariate genetic item-level analyses to examine the ontology and the genetic and environmental etiology of the Big Five personality dimensions, as measured by the NEO Five Factor Inventory (NEO-FFI) [Costa and McCrae, Revised NEO personality inventory (NEO PI-R) and NEO five-factor inventory (NEO-FFI) professional manual, 1992; Hoekstra et al., NEO personality que...

Including a method factor on which all items loaded significantly improved fit of CFAs of both IPIP and NEO-FFI data. Fit was further improved by separating the method factor into two factors representing construct-positive and construct-negative items. The criterion-related validity of conscientiousness increased when uncontaminated by method bias. PRESS PARAGRAPH This research extends previou...