This paper examines the optimal production lot size decisions for clinical trial supply chains. One unique aspect of clinical trial supply chains is the risk of failure, meaning that the investigational drug is proven unsafe or ineffective during human testing and the trial is halted. Upon failure, any unused inventory is essentially wasted and needs to be destroyed. To avoid waste, manufacture...

Abstract This study presents the new petrology and geochemistry data for comprehension of origin emplacement conditions Lolodorf mafic rocks whitin Nyong Complex. The meta-mafic consist fine-grained garnet (FGM) coarse-grained (CGM) presenting nearly similar mineral composition. They are made up quartz, plagioclase, orthopyroxene, clinopyroxene, amphibole, opaques, apatite rutile. also present ...

In the coordinated lot-size problem, a major setup cost is incurred when at least one member of a product family is produced and a minor setup cost for each different item produced. This research consolidates the various modeling and algorithmic approaches reported in the literature for the coordinated replenishment problem with deterministic dynamic demand. For the two most effective approache...

With an increasing rate of protein expressions the need for fast protein characterization has become more important. Protein NMR has long been an important contributor for protein characterization; being one of a few techniques that can study proteins at atomic resolution in their native state. Whitin recent years faster experimental and processing methods have emerged that are now becoming rou...

Within the framework of reverse logistics, the classic economic lot-sizing problem has been extended with a remanufacturing option. In this extended problem, known quantities of used products are returned from customers in each period. These returned products can be remanufactured, so that they are as good as new. Customer demand can then be fulfilled both from newly produced and remanufactured...

BACKGROUND The aim of this study was to investigate the percentage of the stem cells population in human endometrial tissue sections and cultured cells at fourth passage. METHODS Human endometrial specimens were divided into two parts, one part for morphological studies and the other part for in vitro culture. Full thickness of human normal endometrial sections and cultured endometrial cells ...

Nowadays, medical imaging procedures provide a great variety of data obtained with different modalities. To offer a deeper insight into this data the simultaneous visualization of these images, not regarding their source, must be provided. One example is the field of functional brain imaging, where the activation of brain regions during cognitive tasks is measured. This data has to be visualize...

In this paper, we consider inventory models for periodic-review systems with replenishment cycles, which consist of a number of periods. By replenishment cycles, we mean that an order is always placed at the beginning of a cycle. We use dynamic programming to formulate both the backorder and lost-sales models, and propose to charge the holding and shortage costs based on the ending inventory of...