Withania somnifera (L.) Dunal is an important ayurvedic medicinal plant known mainly for its rejuvenating properties. In vitro micropropagation or multiplication of Withania somnifera through apical shoot proliferation by using different concentrations of growth regulators in short period. Shoots were induced from the apical meristem of Withania somnifera on Murashige and Skoog (MS) basal media...

Withania somnifera is one of the most valuable medicinal plants synthesizing secondary metabolites known as withanolides. Despite pharmaceutical importance, limited information is available about the biosynthesis of withanolides. Chemo-profiling of leaf and root tissues of Withania suggest differences in the content and/or nature of withanolides in different chemotypes. To identify genes involv...

Withania somnifera, popularly known as Ashwagandha is widely considered to be an integral part of Ayurvedic and Indigenous medical systems for over centuries for the treatment of various ailments. Withanolides (steroid lactone), are the major active constituents present in the roots and leaves of Withania somnifera. In the present study, withaferin A (active component of Withania somnifera), a ...

OBJECTIVE The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology. MATERIALS AND METHODS In the present study, arsenic in the form of sodium arsenite was administered orally ...

The present study was to compare the Phytochemical and Antimicrobial analysis of W. somnifera and W. obtusifolia. In the Ethanolic leaf and root extract of Withania species were screened for phytochemical compounds by qualitative and FT-IR, UV method. Withania species have been used for remedies of human pathogen because they contain therapeutic compounds. This research work was mainly focused ...

The Chinese lantern, which is the inflated calyx syndrome (ICS) of Physalis, is formed by MPF2 in the presence of the plant hormones, cytokinin and gibberellin. MPF2 knockdown mutants of Physalis have small leaves, no ICS, and are male sterile, thus, revealing three MPF2-related functions. Of the close relatives of Physalis, Tubocapsicum has only a rudimentary calyx, whereas others, like the Wi...

Five medicinal plants of Pakistan were investigated for their antinociceptive, anti-inflammatory, antidepressant, and anticoagulant potential. Antinociceptive activity was estimated by hot plate and writhing assay. In hot plate assay, Quercus dilatata (52.2%) and Hedera nepalensis (59.1%) showed moderate while Withania coagulans (65.3%) displayed a significant reduction in pain. On the other ha...

Withania Somnifera Dunal know as Ashwagandha belong Solanaceae family. It is extensively used in most of the Indian herbal pharmaceuticals and nutraceuticals. The current study, evaluate in vitro cytotoxicity in 50% ethanol extract of root, stem and leaves of Withania Somnifera against five human cancer cell lines of four different tissues i.e. PC-3, DU-145 (prostrate), HCT-15 (colon), A-549 (l...

The present study was carried out to investigate the changes in oxidative and inflammatory status in streptozotocin-induced diabetic rat's kidneys and serum following treatment with Withania coagulans, a popular herb of ethnomedicinal significance. The key markers of oxidative stress and inflammation such as inflammatory cytokines (IL-1β, IL-6, and TNF-α) and immunoregulatory cytokines (IL-4 an...

The yield parameters and cost economics of Withania somnifera were studied using Integrated Nutrient Management (INM) treatments. Withania somnifera is cultivated in around 10,780 ha with a production of 8429 tones in India. The annual demand of this herb increased from 7028 tones (2001-2002) to 9127 tones (2004-2005). The field experiment was conducted at the research farm of Department of Pla...