A double-blind, placebo-controlled study was conducted to evaluate the efficacy an ethanolic extract of Aswagandha (Withania somnifera), in patients with ICD-10 anxiety disorders. The sample comprised 39 subjects, of whom 20 received the drug and 19 received placebo. The two groups were sociodemographically and clinically similar at baseline. At 2 and 6 weeks follow-up, data from approximately ...

Withania somnifera (Ashwagandha) is a very revered herb of the Indian Ayurvedic system of medicine. It is useful for treating various kinds of disease processes and especially used as a nervine tonic. Withania somnifera (Ws) contain a wide array of active components including withaferin A, withanone and other flavonoids exhibiting strong anti-oxidant properties. Many scientific studies on Ws we...

Withania somnifera an Indian traditional medicinal herb, is known to possess antistress, antioxidant, analgesic, anti-inflammatory, cardioprotective, adaptogenic, antispasmodic, immunomodulatory and immunostimulant activities. Its other activities include anti-inflammatory, immunoregulatory, anti-tumor, anti-angiogenic, antiinvasive and chemopreventive effects. We investigated the antioxidant, ...

Withania somnifera (L.) Dunal known as Ashwagandha is commonly used in traditional Indian medicine system. It possesses immense therapeutic value against a large number of ailments such as mental diseases, asthma, inflammation, arthritis, rheumatism, tuberculosis, and a variety of other diseases including cancer. The therapeutic potential of W. somnifera is due to the presence of secondary meta...

Peripheral blood is an accessible adult stem cell source for both basic and applied research including clinical applications. Peripheral blood mononuclear cells (PBMCs) were reported to possess multipotent progenitor cell populations and has the potential to differentiate into blood cells, endothelial cells, hepatocytes, cardiomyogenic cells, smooth muscle cells, osteoblasts and so on. They can...

A phospholipase inhibitor (WSG) has been purified from Withania somnifera using gel-filtration and ion-exchange chromatographies. The WSG is an acidic glycoprotein. Its molecular mass as determined by SDS-PAGE was 27kDa. It neutralized the enzyme activity and pharmacological properties such as cytotoxicity, edema, and myotoxicity of a multi-toxic Indian cobra venom phospholipase (NNXIa-PLA) but...

Withania somnifera (L.) Dunal is an important medicinal plant with many pharmaceutical and therapeutic uses ranging from immunomodulation to anticancer property. Field cultivation of W. somnifera is time consuming and it not able to meet current global demands. For commercial production of withanolides, field grown plant materials have generally been used but the quality and uniformity in the l...

The present study investigated the possible protective role of Withania somnifera (Linn.) Dunal (Solanaceae) root powder against bromobenzene-induced oxidative damage in rat liver mitochondria. Administration of bromobenzene (10 mmol/kg body weight) to rats resulted in increased levels of liver marker enzymes, lipid peroxidation, TNF-α, IL-1β and VEGF. There was also marked depletion in the lev...