Background: Since both fetal and postnatal development is determined by early embryonic the molecular mechanism organogenesis process of mouse embryos have been thoroughly studied. However, specific in Mongolian sheep remains poorly understood. Methods: The 16-day 25-day embryo samples Inner Mongolia Hulunbuir short-tailed were evaluated transcriptome sequencing technique genes with significant...

Background: Variations in DNA methylation levels in the placenta are thought to influence gene expression and are associated with complications of pregnancy like fetal growth restriction (FGR). The most important cause for FGR is placental dysfunction. We here questioned whether changes in DNA methylation, followed by gene expression changes, are mechanistically involved in the etiology of FGR....

OBJECTIVES Signaling by fibroblast growth factor (FGF) receptor (FGFR) 2IIIb regulates branching morphogenesis in the mammalian lung. FGFR2IIIb is primarily expressed in epithelial cells, whereas its ligands, FGF-10 and keratinocyte growth factor (KGF; FGF-7), are expressed in mesenchymal cells. FGF-10 null mice lack lungs, whereas KGF null animals have normal lung development, indicating that ...

Some scholars claim that the type of problems with which private welfare agencies deal varies with agency auspices--whether administrative control is national or local, religious or secular. However, there are few empirical discussions of the issue. This paper thus develops and tests hypotheses concerning how auspices relate to the social problems that agencies cover. Results support a series o...

The aim of the present study was to examine the molecular factors associated with the prognosis of colon cancer. Gene expression datasets were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases to screen differentially expressed genes (DEGs) between colon cancer samples and normal samples. Survival‑related genes were selected from the DEGs using the Cox regress...

BACKGROUND Despite successful treatment and CD4+ T-cell recovery, HIV-infected individuals often experience a profound immune dysregulation characterized by a persistently low CD4:CD8 T-cell ratio. This residual immune dysregulation is reminiscent of the Immune Risk Phenotype (IRP) previously associated with morbidity and mortality in the uninfected elderly (>85 years). The IRP consists of labo...