BACKGROUND Sheets of cells move together as a unit during wound healing and embryonic tissue movements, such as those occurring during gastrulation and neurulation. We have used epithelial wound closure as a model system for such movements and examined the mechanisms of closure and the importance of the Rho family of Ras-related small GTPases in this process. RESULTS Wounds induced in Madin-D...

OBJECTIVES To define the outcome of treatment for deep sternal wound infections (DSWIs) using direct wound closure (DC) or vacuum-assisted therapy (VAT) based on negative vs. positive microbiological results. METHODS Between 1999 and 2008, 7746 patients underwent median sternotomy for cardiac surgery at our institution. Patients were screened for DSWI and out of the cohort 159 were identified...

radiation-related wounds challenge surgeons in all disciplines of surgery. wound-healing complications are commonplace, and solutions for reconstruction are limited. muscle and musculocutaneous flaps have improved this situation. but the question is, does previous radiation of the muscle to be transposed affect the outcome? 143 consecutive previously irradiated patients treated with muscle or m...

Of 110 consecutive open tibial fractures 90 were reviewed and analysed retrospectively with particular reference to wound closure, method of stabilisation, infection rate and the incidence of non-union. There were 41% Gustilo type I, 39% type II and 20% type III injuries. The incidence of deep infection was 20% after primary wound closure compared with 3% after delayed closure, and eight of the...

Stoma reversal is a commonly performed procedure. Surgical site infection (SSI) is one of the most common complications following stoma reversal with reported incidence of up to 41% [1,2]. Surgical site infection leads to increased medical cost, requires additional wound care and extra medications. It might also prolong length of hospital stay and adversely affect quality of life [3,4]. Followi...

BACKGROUND For the noncolonized wound, achieving tension-free, primary wound closure is ideal. Some surgeons advocate imbrication of deeper tissues rather than undermining, posing that imbrication preserves more dermal perfusion while still reducing tension at the wound edge. We sought to determine which technique most reliably reduced wound tension while preserving dermal wound perfusion. ME...

Background Negative Pressure Wound Therapy (NPWT) is primarily used for very complex chronic wounds. The surgical treatment of the diabetic wounds with loss of soft tissue usually consists of closure using split-thickness skin grafts or transposition flaps. However, the first step consists of standard wound care with moist gauze dressing with the aim to prepare the wound bed for final closure. ...

PURPOSE To compare between hand closure and Carter-Thomason technique with respect to following parame­ters, time taken for port site closure, wound infection, wound dehiscence, seroma formation, port site herniation, and ascitic fluid leak. MATERIALS AND METHODS In this study, 200 cases who underwent laparoscopic donor nephrectomy were selected and divided into two groups based on closure te...

Wound healing proceeds by a number of (partially) overlapping steps: bleeding, blood clotting, removal of contaminants and bacteria, wound closure by cell mitosis and migration towards the wound center, repair of the vascular network, and wound contraction along lines of equal tension. We consider a model due to Adam [1] for the closure of a wound. The model is based on an epidermal growth fact...