A new series of chalconesemicarbazones was synthesized and evaluated for anticonvulsant activity by MES Method. Most of the compounds were found to be more or comparable potent than the reference standard drug in the acetic acid-induced writhing test.

BACKGROUND Moringa oleifera Lam (Moringaceae) is a highly valued plant, distributed in many countries of the tropics and subtropics. It has an impressive range of medicinal uses with high nutritional value. METHODS The commercially processed M. oleifera was extracted using methanol as its solvent. Phytochemical analysis as well as the anti-oxidant properties of this supplement were also inves...

In the present study, the antinociceptive profiles of hop extract were characterized in ICR mice. Hop extract administered orally (from 25 to 100 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Antinociceptive action of hop extract was maintained at least for 60 min. Moreover, cumulative response time of nociceptive behavi...

In the present study, we investigated the role of 5-hydroxytryptamine type 3 (5-HT(3)) receptors in hypnosis and analgesia induced by emulsified sevoflurane. A mouse model of hypnosis and analgesia was established by an intraperitoneal or subcutaneous injection of emulsified sevoflurane.We intracerebroventricularly (i.c.v.) or intrathecally (i.t.) administered YM-31636, a 5-HT(3) receptor agoni...

Objective: Berberis vulgaris has antioxidant, hepato--renal protective, antibacterial, lipid lowering, anti-inflammatory and antinociceptive activities. The genus Berberis, has another member called Berberisintegerrima which has not been studied for antinociceptive activity and therefore, this study was aimed to examine the antinociceptive effect oftotal extract and alkaloid fractions of Berber...

Geodorum densiflorum, Diospyros blancoi, Baccaurea ramiflora and Trichosanthes dioica are four important medicinal plants used traditionally in various diseases. Different parts of these plants have been used in different painful conditions. Therefore, the present study was designed to investigate the analgesic activities of methanol extract of pseudobulb of G. densiflorum, seeds of D. blancoi,...

Tinospora crispa, a plant belonging to the family of Menispermaceae is a well-known traditional medicinal plant used in Bangladesh. This study has carried out to evaluate the analgesic (by acetic acid induced writhing test) activities by using Swiss albino mice as a test animal. At a dose of 400 mg/kg body weight, the crude methanol extract and its other fractions of stem significantly (p<0.05)...

In the traditional medicine, Taxus baccata Linn. has been used as analgesic, anticonvulsant, and antiinflammatory remedy. In the present study, bark of plant was extracted with 95% ethanol and ether at room temperature and evaluate for their analgesic activity in mice using the tail-flick and acetic acid-induced writhing method. Ether extract exhibits potent analgesic activity in tail-flick tes...