Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disorder due to mutations in the EIF2AK3 gene. It is characterized by permanent neonatal diabetes mellitus, skeletal dysplasia, liver impairment, neutropenia and renal dysfunction. Liver is the most commonly affected organ and liver failure is the commonest cause of death in this syndrome. The EIF2AK3 gene encodes a transmembrane pro...

Probiotic bacteria Escherichia coli Nissle (EcN) was shown to prevent or heal acute murine colitis, but gastroprotective effects of EcN against mucosal injury have been little studied. In this study, the effects of EcN on formation of stress-induced gastric erosions were assessed in rats. Rats were divided in following treatment groups: 1) vehicle (control); 2) EcN 10(1) CFU/ml; 3) EcN 10(4) CF...

Baker's asthma is the most prevalent occupational asthma, and IgE-mediated response is known as a major pathogenesis. However, recent studies have suggested the involvement of innate immune response because wheat flour contains bacterial endotoxins or lipopolysaccharides. To further understand a role of innate immune response in the development of work-related respiratory symptoms (WRS) in bake...

In cold rolling of silicon steel strip, edge drop directly affects the side cutting and yield steel. To improve in process, a multi-stand coordinated control strategy model based on multi-objective optimization are proposed. The first step is to analyze influence each stand work roll shifting (WRS) through finite element (FEM), then determine effectiveness actuator. Meanwhile, fitting proposed ...

The problem of random sampling without replacement (RS) calls for the selection of m distinct random items out of a population of size n. If all items have the same probability to be selected, the problem is known as uniform RS. Uniform random sampling in one pass is discussed in [1, 5, 10]. Reservoir-type uniform sampling algorithms over data streams are discussed in [11]. A parallel uniform r...

Palm tocotrienol-rich fraction (TRF), an extract from palm oil containing both tocotrienol and tocopherol, is known for its antioxidant effect. The present study investigated the effect of palm TRF on the stomach using a water immersion restraint stress (WRS) model. Fortytwo male Sprague-Dawley rats were divided into three groups and were administered 60 mg/kg/d of palm TRF, α-tocopherol or veh...

BACKGROUND Vineyard workers (VW) are exposed to various respiratory allergens. The aims of the study were to determine the prevalence of work related respiratory symptoms (WRS) in Champagne VW in France and to analyze the relationships between symptoms, occupational exposure and sensitization profile. METHODS VW of Reims area were prospectively recruited between 2007 and 2010. Demographic and...

PURPOSE This study examined differences in voiced consonant-vowel (CV) perception in older listeners with normal hearing and in 2 groups of older listeners with matched hearing losses: those with good and those with poor word recognition scores. METHOD Thirty-six participants identified CVs from an 8-item display from the natural voiced initial consonants/b, d, g, m, n, eth, v and z/in three ...

BACKGROUND Work-related stress (WRS) is known to cause ill-health and decreased productivity. Work in the education sector is thought to be particularly stressful. Few studies have considered risk factors for WRS and health in head teachers. AIMS To investigate health in head teachers in West Sussex. To determine personal risk factors most likely to predict cases of WRS and of poor health in ...

Ethical, legal and societal implications (ELSI) in the development of wearable robots (WRs) are currently not explicitly addressed most guidelines for WR developers. Previous work has identified ELSI related to WRs, e.g., impacts on body identity, ableism, data protection, control responsibilities, but translation these concerns into actionable recommendations remains outstanding. This paper pr...