introduction: leukemia is a malignant disorder resulting from clonal proliferation of lymphoid or myeloid precursors with arrested maturation. it has been shown recently that telomers and telomerase activity are involved in the control of cell proliferation, regulation of cell senescence in the most somatic cells, and unlimited proliferation capacity of the malignant cells including leukemic ce...

Haematologica vol. 85(4):April 2000 2. Borgström GH, Vuopio P, De la Chapelle A. Polyploidy of the bone marrow. Scand J Haematol 1976; 17:12331. 3. Espinet B, Solè F, Woessner S, Florensa L, Besses C, Sans-Sabrafen J. Two new cases of near-tetraploidy in adult acute myeloid leukemia. Cancer Genet Cytogen 1998; 102:131-4. 4. Lemez P, Michalova K, Zemanova Z, et al. Three cases of near-tetraploid...

Human T-cell lymphotropic virus type 1 , 2 (HTLV-1, 2) is endemic in Particular Areas of the world in which it is associated with myeloid leukemia.In this study, we described the prevalence of HTLV-1, 2 in myeloid leukemia and Mycobacterium Tuberculosis in Iran. We have worked with tissue and blood samples for 2 years. These were the same samples which were positive for myeloid leukemia, Mycoba...

3. Mattsson J, Uzunel M, Remberger M, et al. Minimal residual disease is common after allogeneic stem-cell transplantation in patients with B cell chronic lymphocytic leukemia and may be controlled by graft-versus-host-disease. Leukemia. 2000;14:247-254. 4. Mehta J, Powles R, Singhal S, Iveson T, Treleaven J, Catovsky D. Clinical and hematological response of chronic lymphocytic leukemia and pr...

T-Cell Acute Lym-phoblastic Leukemia In article number 2205854, Jingjing Ye, Min Ji, Chunyan and co-workers observed aberrant adipogenesis in the bone marrow of chemotherapy-treated T-cell acute lymphoblastic leukemia (T-ALL) patients, differentiated-adipocytes attract support residual T-ALL cells. Last, an SREBF1 inhibitor demonstrates superior improvement on therapeutic effect dexamethason by...

The TEL-JAK2 gene fusion, which has been identified in human leukemia, encodes a chimeric protein endowed with constitutive tyrosine kinase activity. TEL-JAK2 transgenic expression in the mouse lymphoid lineage results in fatal and rapid T-cell leukemia/lymphoma. In the present report we show that T-cell leukemic cells from EmuSRalpha-TEL-JAK2 transgenic mice present an aberrant CD8(+) differen...

APCs are essential for the orchestration of antitumor T cell responses. Batf3-lineage CD8α+ and CD103+ dendritic cells (DCs), in particular, required spontaneous initiation CD8+ priming against solid tumors. In contrast, little is known about that regulate responses hematological malignancies. Using an unbiased approach, we aimed to characterize responsible regu...

Rearrangements of the T cell ‘y (T y) gene were studied in primary neoplastic cells from 75 patients with leukemia or lymphoma. T y gene rearrangements were observed in 19 of 21 T cell neoplasms; 14 of 21 immature B cell leukemias. including 4 out of 5 patients with rearrangements of both immunoglobulin heavy-chain (JH) and T cell receptor /9 chain (T/9) genes; none out of 14 B cell neoplasms; ...

Chronic lymphocytic leukemia/small lymphoma (CLL/SLL) is an indolent small B-cell neoplasm that may transform into a clinically aggressive disease, namely Richter syndrome, usually as diffuse large lymphoma. Besides, CLL/SLL encompasses increased risk of developing other secondary cancers, including variety T-cell lymphomas, often the anaplastic large-cell type or with cytotoxic phenotype. Here...

Human T-cell lymphotropic virus type 1 , 2 (HTLV-1, 2) is endemic in Particular Areas of the world in which it is associated with myeloid leukemia.In this study, we described the prevalence of HTLV-1, 2 in myeloid leukemia and Mycobacterium Tuberculosis in Iran. We have worked with tissue and blood samples for 2 years. These were the same samples which were positive for myeloid leukemia, Mycoba...