نتایج جستجو برای: y snps
تعداد نتایج: 516966 فیلتر نتایج به سال:
BACKGROUND Colorectal cancer is the third most common cancer in both men and women in the world and the second leading cause of cancer-related deaths. The incidence of colorectal cancer has increased in Iran in the past three decades and is now considered as a serious problem for our society. This cancer has two types hereditary and non-hereditary, 80% of cases being the latter. Considering tha...
We describe a new computer program, SnpEff, for rapidly categorizing the effects of variants in genome sequences. Once a genome is sequenced, SnpEff annotates variants based on their genomic locations and predicts coding effects. Annotated genomic locations include intronic, untranslated region, upstream, downstream, splice site, or intergenic regions. Coding effects such as synonymous or non-s...
در مطالعه حاضر دو پلی مرفیسم تک نوکلئوتیدی single nucleotide polymorphisms;(snps) در نواحی t129c در اگزون 1 و t1236c در اگزون 12 ، ژن mdr1 در 200 بیمار مصروع ایرانی ( شامل دو گروه بیماران مصروع مقاوم به دارودرمانی و بیماران مصروع پاسخ دهنده به درمان دارویی، هر گروه 100 نفر) در کنار 100 نفر سالم به روشrflp pcr- مورد بررسی و تعیین ژنوتیپ قرار گرفت و فراوانی ژنوتیپ و هاپلوتیپی در این سه دسته مقایس...
BACKGROUND Alcohol dependence is more common among men than among women. Potential explanations for this include the role of genes in sex chromosomes (X and Y). In the present study, we scanned the entire Y chromosome and its homologs on the X chromosome in men to identify male-specific risk genes for alcohol dependence. METHODS Two thousand nine hundred and twenty-seven individuals in two in...
The Genographic Project is an international effort aimed at charting human migratory history. The project is nonprofit and nonmedical, and, through its Legacy Fund, supports locally led efforts to preserve indigenous and traditional cultures. Although the first phase of the project was focused on uniparentally inherited markers on the Y-chromosome and mitochondrial DNA (mtDNA), the current phas...
Haplotype probabilities have been implemented in association analyses performed between three candidate genes and the preweaning survival of F2 Iberian x Meishan piglets, under a categorical proportional hazard model. The additive effect of substitution of each haplotype was estimated using information of parental genotypes for non-genotyped piglets. Analysed loci were the bone morphogenetic pr...
BACKGROUND Chronic psychosocial stress is a crucial risk factor in the development of many diseases including obesity. Neuropeptide Y (NPY), distributed throughout the peripheral and central nervous system, is believed to pay a role in the pathophysiologic relationship between stress and obesity. Although several animal studies have investigated the impact on obesity of interactions between NPY...
Increasing phylogenetic resolution of the Y chromosome haplogroup tree has led to finer temporal and spatial resolution for studies of human migration. Haplogroup T, initially known as K2 and defined by mutation M70, is found at variable frequencies across West Asia, Africa, and Europe. While several SNPs were recently discovered that extended the length of the branch leading to haplogroup T, o...
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