Type 1 Diabetes (T1D) is an autoimmune disease resulting in insulin deficiency as a result of autoimmune destruction of pancreatic β-cells. Preserving β-cell function in patients with T1D would be of great benefit since patients with sustained endogenous insulin secretion are known to suffer less from secondary complications due to hyperglycemia. Glutamic acid decarboxylase 65 (GAD65) is a majo...

Within the context of the theoretical debate on gender and science, the article discusses the process of redefining gender and sex differences using so-called biological or natural markers. It identifies how gender differences undergo naturalization using a logic of 'substantialization or 'materialization'. This process is exemplified in how medicine views women, promoting explanatory models of...

MOTIVATION Reliable identification of protein families is key to phylogenetic analysis, functional annotation and the exploration of protein function diversity in a given phylogenetic branch. As more and more complete genomes are sequenced, there is a need for powerful and reliable algorithms facilitating protein families construction. RESULTS We have formulated the problem of protein familie...

HENRY A. JOHNSON, 0000 MARK E. JOHNSON, 0000 DINCHEN A. KLEIN, 0000 LAURA A. KNABB, 0000 KIRK A. KREISEL, 0000 ARRON W. LAYTON, 0000 TIFFANY A. LEHANE, 0000 GREGORY D. LEWIS, 0000 JEFFREY M. LISAK, 0000 RONALD B. LOTT, JR., 0000 JAMES MATHES, 0000 TODD D. MOORE, 0000 JEFFREY A. NESHEIM, 0000 RICK L. NICKERSON, 0000 GREGORY J. OSTIDIEK, 0000 NANNETTE M. PACO, 0000 CHRISTOPHER F. POULIOT, 0000 JA...

In the terms of operational calculus the probability characteristics of direct and reverse residual renewal time of alternating renewal process, where renewal time depends on life-time, are found. 1. Definitions, Motivations and Formulation of the Problem 1.1 According to [1] let’s consider a system which fails after random life-time X1 and is fully renewed after the lapse of random time Y1. Th...

Despite the enormous media coverage that the issue of year 2000 (Y2K) readiness has received in recent months, the focus of that coverage has been restricted almost exclusively to technological aspects. Non-technical issues have tended to be either ignored completely or given very little attention. Most importantly, not much is known about the organisational processes of preparing to face this ...

I discuss the physics reach of a fixed-target charm experiment which can reconstruct >10 charm decays, three orders of magnitude beyond the largest extant sample. Such an experiment may run at Fermilab shortly after the Year 2000. In addition to “programmatic” charm physics such as spectroscopy, lifetimes, and tests of QCD, this “Charm2000” experiment will have significant sensitivity to new ph...

The Image Reduction and Analysis Facility is a scientific image processing package widely used throughout the astronomical community. IRAF has been developed and distributed by the National Optical Astronomy Observatory in Tucson, Arizona since the early 1980’s. Other observatories and projects have written many dozens of layered external application packages. More than ten thousand journal art...

Many inscriptions from Pu Sindok's reign (929–948) can be discovered across eastern Java. The researchers have found 23 with year dates that detail the laws were in effect under rule. Policies are written as sima makudur and punpunan. Because there so many sources these inscriptions, it is possible to recreate historical events assess his implemented policies. This article uses Robert K. Merton...