Zoledronic acid (ZA) has been tested in clinical trials as an additive therapy for early-stage breast cancer. However, the mechanism by which ZA exerts its antitumor activity is still unclear. The aim of this study is to investigate whether the prevention of tumor growth by ZA is through regulating the mesenchymal stem cells (MSC)-monocyte chemotactic protein 1 (MCP-1)-macrophages axis in the t...

Due to their inhibitory effects on resorption, bisphosphonates are widely used in the treatment of diseases associated to an extensive bone loss. Yet, little is known about bisphosphonates effects on newly-formed bone quality. In the present study, adult male Sprague-Dawley rats (n=80) with a bone defect calvaria area were used and short-term effects of zoledronic acid (ZA) were studied on the ...

Polazi se od tvrdnje da se kvalitativni pristup određivanju popisa prvenstva u upravljanju rizicima primjenjuje kada nije na raspolaganju odgovarajuća baza podataka ili nema dovoljno pokazatelja za izračunavanje. Prikazane su najčešće rabljene tehnike za kvalitativnu analizu rizika. Usporedbom triju tehnika pokazano je da je Analitički hijerarhijski pristup (AHP) najpotpunija i najprilagodljivi...

This paper presents SPIN, a semantic parser developed for spoken dialog systems. The parser provides a powerful rule language for an easy and efficient creation of the rule set. Important features of the rule language include order-independent matching, built-in support for referring expressions, rule ordering, constraints and action functions. On the basis of an example utterance the advantage...

BACKGROUND Zoledronic acid (ZA) has antiresorptive effects and protects from bone metastasis in women with early breast cancer. In addition, in postmenopausal women with endocrine responsive breast cancer ZA prolongs DFS. The exact mechanism is still unclear. We have therefore investigated the effect of increasing concentrations of ZA in breast cancer cell lines in the absence or presence of es...

Epithelial cells contain noncentrosomal microtubules (MTs), whose minus ends are oriented apically. In contrast with the well-known interactions of the minus ends with the centrosome, little is known about the termination site of the noncentrosomal minus ends. Here we show that a population of MT minus ends is anchored at the zonula adherens (ZA), the apical-most part of the cadherin-based adhe...

Vγ9Vδ2 T cells play a major role as effector cells of innate immune responses against microbes, stressed cells, and tumor cells. They constitute <5% of PBLs but can be expanded by zoledronic acid (ZA)-treated monocytes or dendritic cells (DC). Much less is known about their ability to act as cellular adjuvants bridging innate and adaptive immunity, especially in patients with cancer. We have ad...

Zoledronic acid has shown indirect anticancer effects on angiogenesis, the tumor microenvironment and immune responses. Its immunological action is exerted, at least in part, via its modulating properties. The aim of this study was to investigate the in vitro effects of zoledronic acid on the dendritic cells of melanoma patients. Peripheral blood samples were collected from 26 patients with mel...

BACKGROUND Zoledronic acid (ZA) reduces locoregional and distant metastases in estrogen receptor (ER)-positive breast cancer patients. Since ZA rapidly concentrates in the bone following i.v. administration, we hypothesized that this phenomenon involves the mechanism of action of ZA in bone tissue. MATERIALS AND METHODS Migration assays were carried out in fibronectin-coated Boyden chambers. ...

Povzetek. V tem prispevku podajamo pregled obstoječih in prihajajočih metod lociranja v mobilnem okolju. Z rastjo mobilnih tehnologij in povečano uporabo ter razširitvijo mobilnih terminalov, mobilne storitve in aplikacije, med njimi tudi tako imenovane lokacijske storitve, pridobivajo čedalje več pozornosti. Kontekst uporabe je pomemben element za personalizacijo bodočih sistemov za pridobivan...