Acrolein is the most reactive aldehydic product of lipid peroxidation and is found to be elevated in the brain when oxidative stress is high. The effects of acrolein on the structure and function of human Cu,Zn-superoxide dismutase (SOD) were examined. When Cu,Zn-SOD was incubated with acrolein, the covalent crosslinking of the protein was increased, and the loss of enzymatic activity was incre...

Understanding the effect of temperature on the speciation of multivalent metals in solution is essential for many applications in industry. The results of the present Cu(II) and Zn(II) solutions speciation studies in tandem with thermodynamic calculations have shown that Cu or Zn ions proliferate in acidic solutions whilst in alkaline medium, solid Cu(OH)2 or Zn(OH)2 colloidal particles form. T...

Structural characterization, exploiting X-ray scattering differences at elemental absorption edges, is developed to quantitatively determine crystallographic site-specific metal disorder. We apply this technique to the problem of Zn-Cu chemical disorder in ZnCu(3)(OH)(6)Cl(2). This geometrically frustrated kagomé antiferromagnet is one of the best candidates for a spin-liquid ground state, but ...

patients and methods serum zn and cu level of 43 patients with brucellosis (34 men and 9 women) were compared with 43 matched healthy controls. serum micronutrient concentrations were measured by automatic absorptive spectrophotometry. results mean serum cu concentration was significantly higher in subjects with brucellosis when compared with agematched healthy controls (p<0.05). mean serum zn ...

Heat shock proteins are induced at normal temperatures by oxidants and during reoxygenation following hypoxia. We now report cyanide-resistant O2 consumption increased 30-50% in rat lungs exposed to heat shock or reoxygenation following hypoxia. The synthesis of Cu,Zn superoxide dismutase, but not Mn superoxide dismutase, was increased in rat lung slices by in vivo hyperthermia (39 degrees C), ...

Of the problematic agents in the ecosystem, heavy metals have special importance because they are unabsorbable and have physiologic effects on living beings at low concentrations. This study has investigated the effect of silk worm cocoon on reducing mobility of zinc (Zn) and copper (Cu) for the first time. To this end, 5% cocoon adsorbent was added to the studied soil, which had been contamina...

From flora of North West of Iran, four contrasting species in term of frequency and coverage on heavy metal rich soils were selected to study physiological mechanisms for different tolerance of Zn and Cu toxicity in a hydroponic culture experiment. For study of Zn toxicity, Dactylis glomerata and Secale monatum and for Cu, Cichorium intybus and Astragalus echinops were selected. A clear differe...

Laboratory studies were conducted to determine the effects of different concentrations of Cu, Cd, Zn and mixture (equal concentrations from the three heavy metals) on growth and some oxidative stress (catalase and glutathione reductase) on Scenedesmus obliquus (microalgae) after exposure for 24, 48, and 96 h. In addition, the uptake of Cu, Cd and Zn were determined in the culture medium after 2...

Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-li...

Trace elements play a critical role in the pathogenesis of autism spectrum disorders (ASD). The aim of this study was to investigate the serum levels of zinc (Zn) and copper (Cu) in Chinese children with ASD. Sixty patients (48 males, 12 females) diagnosed with ASD and 60 healthy sex-matched and age-matched control participants were assessed for serum Zn and Cu content at admission. The severit...