The anticonvulsant topiramate not only decreases ethanol consumption in alcohol dependence (AD) but also may produce several adverse events including cognitive impairment. Zonisamide is a structurally related anticonvulsant that is a promising agent for the treatment of AD and may have greater tolerability than topiramate. This study evaluated the effects of zonisamide (400 mg/d) on alcohol con...

Reference 1. Yagi H, Ohkawara B, Nakashima H, Ito K, TsushimaM, Ishii H, et al. (2015) Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model. PLoS ONE 10(11): e0142786. doi: 10.1371/journal.pone.0142786 PMID: 26571146 Fig 4. Zonisamide rescues cell death due to oxidative stress. Primary motor neurons in DMEM/F...

Silicate urinary calculi are rare in humans, with an incidence of 0.2% of all urinary calculi. Most cases were related to excess ingestion of silicate, typically by taking magnesium trisilicate as an antacid for peptic ulcers over a long period of time; however, there also existed unrelated cases, whose mechanism of development remains unclear. On the other hand, zonisamide, a newer antiepilept...

PURPOSE To examine the safety and efficacy of zonisamide in treating myoclonic seizures associated with progressive myoclonic epilepsy (PME), in an open-label setting. METHODS Thirty patients with refractory PME (aged > or = 5 years), who were taking up to three antiepileptic drugs, received adjunctive zonisamide (< or = 6 mg/kg/day) therapy for 16 weeks. Myoclonic seizures were recorded dail...

OBJECTIVE Approximately one third of epileptic children are resistant to anticonvulsant drugs. This study evaluates the effectiveness, safety, and tolerability of pregabalin as adjunctive therapy in epileptic children relative to Zonisamide. MATERIALS & METHODS From April 2012 to November 2012,121 children were referred to Mofid Children's Hospital with intractable epilepsy and enrolled in th...

When a new antiepilepsy agent is being evaluated it is critical, but not always feasible, to have access to two different kinds of information. The first is efficacy data from rigorous, prospective, randomized double-blind trials. The second is information on the drug’s ‘‘effectiveness’’ in a large population of patients, with a broad spectrum of seizure types, who are treated in a more ‘‘real ...

The prophylactic therapy of the episodic (ECH) and chronic cluster headache (CCH) is based on verapamil and carbolithium. Besides several patients are not responders at this drugs. To evaluate the efficacy and tolerability of zonisamide in prophylaxis therapy of ECH and CCH. 11 patients (pz), (4 F,7 M) mean age 42.8 years (SD 5.8), range 36-56 years, suffering from ECH (8pz) and CCH (3 pz) (ICD...

PURPOSE There are a limited number of anticonvulsant medications that can be administered with an oral loading dose in order to rapidly achieve an effective serum level, and most of these have associated adverse effects. Zonisamide is approved for the treatment of partial onset epilepsy, and is used in practice for both generalized and partial onset epilepsy. It is generally well-tolerated, has...

An accurate and very rapid method for determination of zonisamide an antiepileptic drug, in human serum is described. The analytical procedure involves liquid-liquid extraction of the analyte and an internal standard (vanillin) from human serum by ethyl acetate as extracting solvent. Chromatographic separation was achieved using a monolithic C18 analytical column and a mixture of 0.05 M phospha...

This study investigated another type of carbonic anhydrase inhibitor and antiepileptic drug, zonisamide, in order to evaluate its potential effectiveness for migraine prophylaxis refractory to topiramate, and to assess intolerability to adverse events, paresthesia in particular. This is an open-labeled retrospective single center study. We included headache patients who met the requirement of m...