Ephedrine and pseudoephedrine can be used as precursors for the illicit synthesis of stimulant drugs, such methamphetamine methcathinone. For this reason, an enantioselective capillary electrokinetic chromatography method was developed separation ephedrine enantiomers. After testing two different charged or chargeable cyclodextrins (β-cyclodextrin sulphate carboxymethyl-β-cyclodextrin) a few mi...

BACKGROUND AND OBJECTIVES This study examined the association of physical activity and sedentarism with tobacco and alcohol consumption, and adherence to the Mediterranean diet in teenagers of both genders. METHODS A total number of 1897 Spanish teenagers (12-16 year-olds) took part in the present cross-sectional study. The variables were measured by means of questionnaires previously validat...

The fungus Penicillium purpurogenum was found to produce intracellular ß-glucosidase. Maximum activity of ß-glucosidase was observed on sucrose. Various cultural parameters of cultivation of P. purpurogenum for production of ß-glucosidase were optimized. Maximum enzyme content was observed after 96 hours of cultivation at 30°C. Addition of amino acids histidine and cysteine induced ß-glucosidas...

It has been shown that inflammation reduces the effectiveness of sympathetic nerves in the regulation of knee joint blood flow, and the joint vascular- ß adrenoceptors are changed due to acute inflammation from a majority of ß-1 to an equality of ß-1 and ß-2 receptors.. To investigate the role of sympathetic nerves in nerve induced vasoconstriction and changes in joint vascular ß-adrenoceptors ...

Wnt/ß-catenin signaling is strongly implicated in neoplasia, but the role of this pathway in human breast cancer has been controversial. Here, we examined Wnt/ß-catenin pathway activation as a function of breast cancer progression, and tested for a relationship with HER2/neu expression, using a human tissue microarray comprising benign breast tissues, ductal carcinoma in situ (DCIS), and invasi...

The removal of low-polarity organic compounds from soils and aquifers by water flushing is often constrained by sorption interactions. There is great interest in developing systems that can enhance the transport of organic compounds through porous media, thus facilitating remediation. We investigated the potential of hydroxypropylP-cyclodextrin (HPCD), a microbially produced compound, to reduce...

1 Downregulation of Cdk6 kinase activity is crucial for TGF-ß induced growth inhibition (I) ………………………………………………………………………………….38 1.1 TGF-ß growth inhibition is attenuated by overexpression of wild type Cdk6 …………38 1.2 Cyclin D-related kinase activity is maintained in wild type Cdk6-overexpressing cells treated with TGF-ß …..……………………………………………………………….39 1.3 Cdk2-associated kinase activity is partia...

To investigate quantitatively the cooperative binding ability of several beta-cyclodextrin oligomers bearing single or multiligated metal center(s), the inclusion complexation behavior of four bis(beta-cyclodextrin)s (2-5) linked by 2,2'-bipyridine-4,4'-dicarboxy tethers and their copper(II) complexes (6-9) with representative dye guests, i.e., methyl orange (MO), acridine red (AR), rhodamine B...

Bacillus licheniformis RM44 was isolated from hot spring near Karachi and screened forthe production of extracellular amylase Amy RM44. Amy RM44 was purified to homogeneityon a single step by affinity chromatography using insoluble corn starch. The molecular weightof Amy RM44 was estimated to be 66 kDa by SDS–PAGE and zymographic analysis. Nine foldpurification was achieved with the specific ac...