Mechanisms for resistance were studied in three classic type, human small cell lung cancer cell lines, (.!(,,, (.I.(',„,and <;i.<',.i, that were established from one patient during clinical follow-up. Clinically the tumor changed from sensitive (<;!,(,,) to completely resistant to (chemo)therapy ((il.(.',,,) during this period. The stain with JSB-1 anti body, detecting the M, 170,000 multidru...

The electrical potential difference (P.D.) across the cell membrane was measured in monolayers of HeLa cells. At 37°C in the cells' growth medium, the mean P.D. was found to be —1 5.45 ±0.57 my, the cell interior being negative. In Tris buffer the P.D. was —17.10 ±0.71 my. The PD. was tempera ture sensitive, falling to —11.9 my at 27°Cand —9.12my at 17°C.Increasing extracellular K ...

We optimized the modulation of drug resistance by the irreversible augmentation of cytotoxicity of coincubating vinblastine (VNB) with VP16 and the reversible increase in cytotoxicity of coincubation of verapamil (VPL) with VNB and VP-16. VPL was administered as a loading dose (i.v.) (0.15 mg/kg) and then administered as a constant infusion (0.005 mg/kg) over 6 days. 24 h after verapamil, VNB 2...

åÌÓ„Ë ÚÎË (Hemiptera: Aphididae), Í‡Í Ë ÔÓ ̃Ë ̇ÒÂÍÓÏ ̊ ÓÚfl‰‡ Homoptera, ÔËÚ‡ ̨ÚÒfl ÙÎÓ ̋ÏÌ ̊Ï ÒÓÍÓÏ ‡ÒÚÂÌËÈ [2]. Ç Ò‚flÁË Ò ÚÂÏ, ̃ ÚÓ ̋ ÚÓÚ ÒÓÍ ÒÓ‰ÂÊËÚ ÎË ̄ ̧ 20% ÌÂÁ‡ÏÂÌËÏ ̊ı ‡ÏËÌÓÍËÒÎÓÚ, ÌÂÓ·ıÓ‰ËÏ ̊ı ‰Îfl ÌÓχΠ̧ÌÓ„Ó ‡Á‚ËÚËfl Ë ÊËÁ̉ÂflÚÂÎ ̧ÌÓÒÚË ÚÎÂÈ [3], ÔÓÒΉÌË “‚ ̊ÌÛʉÂÌ ̊ ‚ÒÚÛÔ‡Ú ̧” ‚ ÒËÏ·ËÓÚË ̃ÂÒÍË ÓÚÌÓ ̄ÂÌËfl Ò ̋̉ӈËÚÓ·ËÓÚË ̃ÂÒÍËÏË ·‡ÍÚÂËflÏË Ó‰‡ Buchnera, ÍÓÚÓ ̊ ‚ÓÒÔÓÎÌfl ̨Ú Ì‰ÓÒÚ‡ ̨ ̆ËÂ...