The anticataract activity of Acorus calamus roots extract against induced hydrogen peroxide cataractogenesis was assessed in Goat lenses. The in vitro phase of study was performed on lenses from Goat eyes incubated for 52 h at 37oC in Dulbecco Modified Eagle Medium (DMEM) containing H2O2 (0.5 mM) (Group I), in DMEM containing H2O2 (0.5 mM) and methanolic extract of Acorus calamus (MEAC), (Group...

A preparative gas chromatography (pGC) method was developed for the separation of isomers (cis- and trans-asarone) from essential oil of Acorus tatarinowii. The oil was primarily fractionated by silica gel chromatography using different ratios of petroleum ether and ethyl acetate as gradient elution solvents. And then the fraction that contains mixture of the isomers was further separated by pG...

BACKGROUND The growth-inhibiting and morphostructural effects of seven constituents identified in Asarum heterotropoides root on 14 intestinal bacteria were compared with those of the fluoroquinolone antibiotic ciprofloxacin. METHOD A microtiter plate-based bioassay in sterile 96-well plates was used to evaluate the minimal inhibitory concentrations (MICs) of the test materials against the or...

The present study aimed to evaluate possible variations in the chemical composition and antimicrobial activity of essential oils extracted from Piper marginatum leaves obtained by hydrodistillation at pH4, pH7, pH10. When compared, profiles three were different. A reduction major phenylpropanoids Z-asarone, dillapiole, E-asarone was observed for samples pH4-EO pH10-EO as compared sample pH7- EO...

Background Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease which cannot be cured at present. The aim of this study was to assess whether the combined application of β-asarone and tenuigenin could improve the efficacy of memantine in treating moderate-to-severe AD. Patients and methods One hundred and fifty-two patients with moderate-to-severe AD were recruited and a...

Background The aggregation of tau hyperphosphorylation (p-tau) into neurofibrillary tangles (NFT) is a hallmark in the histopathology Alzheimer’s disease (AD). Our previous experiments found that β-asarone could prevent injury PC12 cells induced by A 1–42 , but it fight cell damage p-tau okadaic acid (OA) poorly understood. Objectives emphasis this study lies β-asarone’s therapeutical effect on...