PURPOSE Whereas many studies have focused on the vesical changes of the α1 adrenergic receptor (AR) subtypes in partial outlet obstruction, few studies have addressed the modulation of the α1 AR subtypes after spinal cord injury (SCI). Therefore, we studied the modulation of the α1 ARs in urinary bladder in a rat SCI model. METHODS Four weeks after a SCI, the whole vesical bodies from eight f...

BACKGROUND AND AIMS There is accumulating evidence that sympathetic nervous hyperactivity contributes to the pathogenesis of glomerular sclerosis independent of blood pressure effects. A previous study showed that α1-adrenoceptor (α1-AR) antagonists inhibit mesangial cell (MC) proliferation. However, the underlying mechanism remains unclear. METHODS AND RESULTS We found that α1-AR is expresse...

Suppose that α1,α2,β1,β2∈ℝ. Let α1,α2>1 be irrational and of finite type such 1,α1−1,α2−1 are linearly independent over ℚ. c a real number in the range 1<c<12∕11. In this paper, it is proved there exist infinitely many primes intersection Beatty sequences ℬα1,β1=⌊α1n+β1⌋, ℬα2,β2=⌊α2n+β2⌋ Piatetski-Shapiro sequence

The inhibitory glycine receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on Glycine Receptors) is a member of Cys-loop superfamily transmitter-gated ion channels that includes zinc activated channels, GABAA, nicotinic acetylcholine and 5-HT3 receptors Zn2+- channels. expressed either homo-pentamer α subunits, or complex now thought to harbour 2α 3β subunits [33, 7], contain an intr...

Stimulating antibodies against G-protein-coupled receptors, including the β1- and β2-adrenergic receptors, the α1-adrenergic receptor, and the angiotensin II AT1 receptor, have been described, as well as activating antibodies directed at the platelet-derived growth factor receptor tyrosine kinase. Their existence and actions appear to be established. Lacking are mechanistic studies of receptor ...

BACKGROUND The previous study showed that arylpiperazine can condition affinity to α-adrenoceptors, 5-HT1A/5-HT2A receptors and compounds with arylpiperazine had antidepressant-like effect. The aim of this study was to determine the antidepressant-like activity of new arylpiperazines containing novel 8-alkoxy-purine-2,6-dione fragments. METHODS New 3-chloroarylpiperazinylalkyl analogs of 8-al...

due to the increasing presence of electromagnetic radiation in advanced societies, investigation of the effects of this radiation on humans has attracted the interest of many researchers. the non- ionizing radiation can induce numerous effects through biomolecules in the tissue and cells. in the current study, effects of 12 hz electromagnetic waves investigated on neuronal hormone levels in rat...

Enriched environment (EE) has an important role in the development and plasticity of the brain. In this study, we investigated the maintenance of early EE exposure-induced changes of spatial sensitivity, and the possible underlying mechanisms of this maintenance. We found that, compared with the age-matched control, the spatial sensitivity of A1 neurons was still enhanced after EE rats had been...