For a cell to move forward it must convert chemical energy into mechanical propulsion. Force produced by actin polymerization can generate traction across the plasma membrane by transmission through integrins to their ligands. However, the role this force plays in integrin activation is unknown. Here we show that integrin activity and cytoskeletal dynamics are reciprocally linked, where actin-d...

Nowadays, new schizophrenia treatments are more ambitious than ever, aiming not only to improve psychotic symptoms, but also quality of life and social reinsertion. Our objective is to briefly but critically review the diagnosis of schizophrenia, the atypical antipsychotics sertindole's pharmacology, safety and status, and mainly evaluate the effects of sertindole compared with other second gen...

We discuss the virtual Compton scattering amplitude γ+π → γ+π which enters the reaction π+e → π+e+γ. The low-energy scattering amplitude is divided into a model-independent part, involving only the electromagnetic form factor, and a residual part which contains structure information related specifically to (virtual) Compton scattering. In the limit of vanishing final-photon energy, the residual...

For a given convex polygon with inner angle no less than 2 3 π and boundary edge bounded by [l, αl] for 1 ≤ α ≤ 1.4, where l is a given standard bar’s length, we investigate the problem of triangulating the polygon using some Steiner points such that (i) the length of each edge in triangulation is bounded by [βl, 2l], where β is a given constant and meets 0 < β < 1 2 , and (ii) the number of no...

We have analysed the angular power spectra of the Parkes radio continuum and polarisation survey of the Southern galactic plane at 2.4 GHz. We have found that in the multipole range l = 40–250 the angular power spectrum of the polarised intensity is well described by a power-law spectrum with fitted spectral index αL = 2.37 ± 0.21. In the same multipole range the angular power spectra of the E ...

From the MeOH extract of the leaves of Eugenia uniflora eight compounds were isolated, including one sterol, β-sitosterol (1); two triterpenes, betulinic acid (2) and centelloside C (8); three flavonoids, myricetrin (3), myricetin 3-O-(4’’-O-galloyl)-αL-rhamnopyranoside (4), and myricetin 3-O-β-D-glucopyranoside (5); and two megastigmanes, actinidioionoside (6), and (6S,9R)-roseoside (7). All t...

Heat shock protein 90 (HSP90) is a molecular chaperone that is up-regulated in cancer and is required for the folding of numerous signaling proteins. Consequently, HSP90 represents an ideal target for the development of new anti-cancer agents. The human HSP90 isoform, glucose-regulated protein 94 (GRP94), resides in the endoplasmic reticulum and regulates secretory pathways, integrins, and Toll...