The purpose of the present study was to identify genetic variants which confer susceptibility to chronic kidney disease (CKD) in high- or low-risk subjects defined by conventional risk factors separately. The study population comprised 2828 Japanese individuals, including 434 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2)] and 2394 controls (eGFR > or =60 ml...

The P(i) right arrow over left arrow HOH exchange reaction of oxidative phosphorylation is considerably less sensitive to uncouplers than the P(i) right arrow over left arrow ATP and ATP right arrow over left arrow HOH exchanges. The uncoupler-insensitive P(i) right arrow over left arrow HOH exchange is inhibited by oligomycin. These results and other considerations suggest that the relatively ...

Arrows are major components of diagrams, where they are typically used to facilitate the communication of spatial and temporal knowledge. An automated interpretation of arrow diagrams would be highly desirable in pen-based interfaces. This paper develops a method for deducing possible interpretations of arrow diagrams, which is composed of a uni-directional arrow symbol and one or more componen...

We present Arrow Update Logic, a theory of epistemic access elimination that can be used to reason about multi-agent belief change. While the belief-changing “arrow updates” of Arrow Update Logic can be transformed into equivalent belief-changing “action models” from the popular Dynamic Epistemic Logic approach, we prove that arrow updates are sometimes exponentially more succinct than action m...

People often sketch diagrams to facilitate their communication. If computers understood such diagrams, people could interact with information systems more intuitively using similar multi-modal dialogs that include sketched diagrams. It remains a challenging problem, however, to make computers interpret arrow symbols, which are a frequent and versatile ingredient of such diagrams. This paper dev...