Purpose: The purpose of this study was to determine the objective response rate (ORR) following treatment of canine mast cell tumors (MCT) with toceranib phosphate (Palladia, SU11654), a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. Secondary objectives were to determine biological response ...

Seminal plasma is comprised of the extracellular sperm milieu from spermatogenesis in the testes, through to maturation in the epididymis, as well as secretions from the accessory sex glands. Consisting primarily of proteins, this substance has a multitude of functions in mammalian reproduction. Seminal plasma influences sperm physiology, success of semen freezing, migration of spermatozoa thro...