نتایج جستجو برای: آگونیست gnrh

تعداد نتایج: 7357  

2017

The presence of gonadotropin-releasing hormone (GnRH)-like protein has been previously demonstrated in the bovine folicle. This GnRH-like protein was purified and concluded to be histone H2A. However. neither GnRH peptide nor specific GnRH-immunoreactivity (GnRH IR) has been demonstrated in the bovine folicIe 50 far. Thus. this study focused 00 the detection of specific GnRH-IR using the second...

Journal: :Endocrinology 2000
B E Troskie J P Hapgood R P Millar N Illing

We have cloned the full-length complementary DNA (cDNA) for a GnRH receptor from Xenopus laevis pituitary cDNA and determined its gene structure. The cDNA encodes a 368-amino acid protein that has a 46% amino acid identity to the human GnRH receptor. The X laevis GnRH receptor has all of the amino acids identified in the mammalian GnRH receptors as sites of interaction with the GnRH ligand. How...

Journal: :International journal of oncology 2015
Marina Montagnani Marelli Marilena Manea Roberta M Moretti Monica Marzagalli Patrizia Limonta

It is well established that gonadotropin-releasing hormone receptors (GnRH-R) are expressed in different types of cancers, including castration-resistant prostate cancer (CRPC) and mediate the antiproliferative effect of GnRH analogs. Thus, these compounds are employed as targeting moieties to selectively deliver chemotherapeutic agents to cancer cells. GnRH-III, the decapeptide isolated from t...

Journal: :Reproductive biology 2010
Magdalena Ciechanowska Magdalena Lapot Krystyna Mateusiak Franciszek Przekop

This review is focused on the relationship between neuroendocrine regulation of GnRH/LH secretion and the expression of GnRH and GnRH receptor (GnRHR) genes in the hypothalamic-pituitary unit during different physiological states of animals and under stress. Moreover, the involvement of hypothalamic GABA-ergic, Beta-endorphinergic, CRH-ergic, noradrenergic, dopaminergic and GnRH-ergic systems i...

Journal: :Clinical endocrinology 1988
S E Sauder M S Frager G D Case R P Kelch J C Marshall

To investigate the effects of alterations in GnRH pulse frequency on gonadotrophin secretion, we administered low dose GnRH pulses (25 ng/kg) at hourly or 2-hourly frequencies to eight normal men. All subjects received GnRH pulses i.v. every 2 h for 88 h. Following this, exogenous GnRH was discontinued in four normal men (Group A, GnRH withdrawal), and the frequency of GnRH injections was incre...

Journal: :Human reproduction 2005
Chieko Morimoto Yutaka Osuga Tetsu Yano Yuri Takemura Miyuki Harada Tetsuya Hirata Yasushi Hirota Osamu Yoshino Kaori Koga Koji Kugu Yuji Taketani

BACKGROUND GnRH II is the second form of GnRH and is widely distributed in peripheral tissues of the female reproductive tract as well as in the central nervous system. In the present study, we studied the possible implication of GnRH II in endometriosis. METHODS Effects of GnRH II on 5-bromo-2'-deoxyuridine (BrdU) uptake by cultured endometriotic stromal cells were examined. Effects of GnRH ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Lazar Z Krsmanovic Nadia Mores Carlos E Navarro Krishan K Arora Kevin J Catt

The pulsatile secretion of gonadotropin-releasing hormone (GnRH) from normal and immortalized hypothalamic GnRH neurons is highly calcium-dependent and is stimulated by cAMP. It is also influenced by agonist activation of the endogenous GnRH receptor (GnRH-R), which couples to G(q/11) as indicated by release of membrane-bound alpha(q/11) subunits and increased inositol phosphate/Ca(2+) signalin...

Journal: :Neuro endocrinology letters 2005
Kazimierz Kochman Agnieszka Blitek Monika Kaczmarek Alina Gajewska Gabriela Siawrys Raymond Counis Adam J Ziecik

Gonadotropin releasing hormone (GnRH) is an essential factor in the regulation of synthesis and release of pituitary gonadotropins. After binding to specific receptors and coupling with G proteins, it triggers the intracellular signaling involving the synthesis of inositol phosphates and diacylglycerol. Previously we have showed that certain metal complexes with GnRH, i.e. copper (Cu-GnRH) and ...

Journal: :American journal of physiology. Endocrinology and metabolism 2012
Johanna R Rochester Wilson C J Chung Tyrone B Hayes Pei-San Tsai

The continued presence of gonadotropin-releasing hormone (GnRH) neurons is required for a healthy reproductive lifespan, but factors that maintain postnatal GnRH neurons have not been identified. To begin to understand these factors, we investigated whether 1) fibroblast growth factor (FGF) signaling and 2) interactions with the opposite sex are involved in the maintenance of the postnatal GnRH...

Journal: :Human reproduction 2006
Jan Tesarik André Hazout Raquel Mendoza-Tesarik Nicolas Mendoza Carmen Mendoza

BACKGROUND GnRH agonist was recently suggested as a novel luteal-phase support that may act at different levels, including the pituitary gonadotrophs, the endometrium and the embryo itself. This prospective randomized study evaluates the effect of GnRH agonist administered in the luteal phase on ICSI outcomes in both GnRH agonist- and GnRH antagonist-treated ovarian stimulation protocols. MET...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید