Recent evidence shows that the DNA repair protein Ku is expressed on the surface of a subset of cells, where it contributes to adhesion and invasion processes, and also to viral or bacterial entry into target cells. Here, we show that Ku was expressed on the cell surface during activation of human monocytes and that its expression was independent of the conventional endoplasmic reticulum (ER)/G...

The antigenic heterogeneity of a long term cultured cell line has not been clearly demonstrated. In the present study, monoclonal antibodies (MoAbs) to an established cell line KU-2 derived from a human renal cell carcinoma were used to analyze antigenic variation of KU-2 and its subclones. Characterization of thus produced MoAbs was attempted by determining the binding ability to other establi...

1Department of Liberal Arts, The Open University of Japan, 2-11 Wakaba, Mihama-ku, Chiba 261-8586, Japan 2Japan Network of People Living with HIV/AIDS, 1-21-12-103, Hyakunincho, Shinjyuku-ku, Tokyo 169-0073, Japan 3Division of Health Administration, TIS Inc., 2-11-1, Nagatacho, Chiyoda-ku, Tokyo 100-6150, Japan 4School of Nursing, Nagoya City University, 1 Kawasumi, Mizuhocho, Mizuho-ku, Nagoya...

1 Biomechanics Section, KU Leuven, Celestijnenlaan 300C, 3001 Leuven, Belgium 2 Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium 3 Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium 4 Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU L...

A new non-linear method for design and analysis of solid state power amplifiers is presented and applied to an aluminum gallium nitride, gallium nitride (AlGaN-GaN) high electron-mobility transistor (HEMTs) on silicon-carbide (SiC) substrate for Ku band (12.4 13.6 GHz) applications. With combining output power of 8 transistors, maximum output power of 46.3 dBm (42.6 W), PAE of 43% and linear ga...

Karar verme ve risk alma davran??lar? bireylerin özel çal??ma hayatlar?nda önemli etkiye sahiptir. Bireylerin karar aras?nda farkl?l?klar görülebilmektedir. Öte yandan birey, do?umundan itibaren, kendisiyle benzer y?llarda do?an di?er ki?ilerin olu?turdu?u ku?ak ad? verilen grubun bir parças? olur. Ku?aklar çe?itli özellikler aç?s?ndan görülmektedir. davran??? da ku?aklar olabilece?i yaz?nda ye...

The Ku70/80 autoantigens (Ku) are the DNA-binding components of a DNA-dependent protein kinase (PK) involved in DNA double strand breaks repairing a V(D)J recombination. Because apoptosis is associated with DNA fragmentation and, consequently, creation of double strand breaks, and a variety of DNA-damaging drugs kill tumor cells by apoptosis, we tested the impact of Ku deficiency on the sensiti...