A series of phenoxybenzylidene aroylhydrazine derivatives were synthesized and their structureswere confirmed using FT-IR and 1H-NMR spectroscopy. Analgesic profiles of all compoundswere examined using abdominal constriction test (writhing test). Most of synthesized compoundsinduced significant reduction in the writhing response as compared with controls. The mostactive compounds exhibited an a...

Zinc is concentrated in the dorsal horn of the spinal cord and has been proposed to alter excitability of primary afferent C-fibers, structures believed to be important in nociceptive transmission. Based on the inhibitory effect of zinc on the activity of various other neurotransmitters that play a role in nociception, we tested the hypothesis that zinc modulates pain transmission. To test this...

Background 
 Ficus religiosa, commonly known as peepal, is widely distributed in Indian subcontinent. It has been used an antiepileptic, aphrodisiac, analgesic, anti-inflammatory and laxative traditional medicine.
 Objective To explore the analgesic effect of aqueous root extract religiosa using thermal chemical models pain swiss albino mice.
 Method The aerial was prepared soxhl...

BACKGROUND The current study was conducted to evaluate the antioxidant, analgesic, antihyperglycemic, neuropharmacological and antidiarrheal activities of ethanolic extract of Lepisanthes rubiginosa L. leaves in different experimental models. METHODS Quantitative and qualitative analysis were done by TLC (thin layer chromatography) and DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scaveng...

This study describes the biological activity of the dried leaves, stem and rhizomes of Curcuma zedoaria belonging to the family Zingiberaceae. The dried powders of the plant were extracted with organic solventsmethanol and pet ether sequentially by the maceration process. The crude extract of methanol and pet ether were then investigated for analgesic and antimicrobial activity. At an oral dose...

The present study was conducted to evaluate the anti-nociceptive and anti-inflammatory properties of an ethanol extract of whole fruit of Lagenaria breviflora (LB) in rat and mice. Analgesic activity was measured by hot plate, formalin-induced paw licking, and acetic acid-induced abdominal writhing tests, while anti-inflammatory activity was determined by inhibition of carrageenan-induced paw o...

In the literature, there are some data which indicate that benzodiazepines and other chemical compounds with the same mechanism of action (Diazepam, Chlordiazepoxide, Lorazepam, Zopiclone, etc.) also have other effects. We investigated the effects of experimental chronic inflammation under the administration of some tranquilizers and hypnotics on peripheral algesia induced in rats by "writhing ...

BACKGROUND The present study was aimed to investigate the antinociceptive and anti-inflammatory activity of the Curcuma zedoaria (family Zingiberaceae) ethanolic rhizome extract in laboratory using both in vitro and in vivo methods so as to justify its traditional use in the above mentioned pathological conditions. METHODS Phytochemical screening was done to find the presence of various secon...