PURPOSE Chemotherapy-induced cognitive impairment (CICI) is a clinically significant problem. Previous studies using magnetic resonance imaging indicated structural changes in the cerebral white matter of patients with CICI. Phosphorylated neurofilament heavy subunit (pNF-H), a major structural protein in axons, was recently reported to be elevated in the serum of patients with some central ner...

[Purpose] The aim of this study was to investigate the change in standing balance of younger persons after neuromuscular joint facilitation (NJF) treatment. [Subjects] The subjects were 57 healthy young people, who were divided into three groups: The NJF group, and the Proprioceptive Neuromuscular Facilitation (PNF) group and the control group. [Methods] Functional reach test and body sway were...

Cervical spine compression with cervical radicular or cervical spinal cord compression is a common neck condition caused by inflammatory diseases, cervical disk degeneration, neck injuries or other less common causes (tumours, infections etc.). The phosphorylated form of the High-Molecular-Weight Neurofilament Subunit NF-H (pNF-H) in Cerebro-Spinal Fluid (CSF) is a specific biomarker for spinal...

[Purpose] Proprioceptive neuromuscular facilitation (PNF) stretching is known to be effective in increasing joint ROM. The PNF stretching technique first induces an isometric contraction in the muscles to be stretched, but no agreement concerning the optimal contraction intensity has yet been reached. The purpose of the present study was to examine the effect of contraction intensity on ROM whi...

Self-assembling peptide nanofibrils (PNF) have gained increasing attention as versatile molecules in material science and biomedicine. One important application of PNF is to enhance retroviral gene transfer, a technology that has been central for therapy approaches. The best-investigated commercially available derived from 12-mer termed EF-C. mechanism transduction enhancement depends on the po...

BACKGROUND Young people tend to over-estimate peer group drinking levels. Personalised normative feedback (PNF) aims to correct this misperception by providing information about personal drinking levels and patterns compared with norms in similar aged peer groups. PNF is intended to raise motivation for behaviour change and has been highlighted for alcohol misuse prevention by the British Gover...

[Purpose] The purpose of this study were to identify whether painless dynamic PNF techniques can reduce lymphedema, and to provide basic reference data for use in the treatment of lymphedema patients. [Subjects] This experiment was conducted from March 2012 to July 2012 at Busan University Hospital D. The subjects were upper extremity lymphedema patients who were receiving rehabilitation treatm...

Neurofibromas are the hallmark of neurofibromatosis type 1 (NF1). Interestingly, generalised and localised interference or dysfunction of bone is also a key element of the NF1 phenotype. In the skull, NF1-associated orbital dysplasia often results in a severe disfigurement of affected individuals. However, the underlying pathology of orbital dysplasia is a complex phenomenon and up to now poorl...

A lambda gtII expression library was prepared from rat brain and screened with a polyclonal antiserum, which recognizes both NF-H and NF-M. An NF-M cDNA clone (pNF-M3C = 1.6 kb) was isolated and characterized. The fusion protein of NF-M3C, when used as an affinity matrix for the anti-neurofilament serum, isolated a subpopulation of antibodies specific for NF-M. Northern analysis demonstrates a ...

Positively charged naturally occurring or engineered peptide nanofibrils (PNF) are effective enhancers of lentiviral and retroviral transduction, an often rate-limiting step in gene transfer therapy approaches. These polycationic PNF thought to bridge the electrostatic repulsions between negatively membranes virions cells, thereby enhancing virion attachment infection target cells. Here, we ana...