A large database of homologous sequence alignments with good estimates of evolutionary distances can be a valuable resource for molecular evolutionary studies and phylogenetic research in particular. We recently created a database containing 159,921 transcripts from human, mouse, rat, zebrafish and fugu species. Approximately 1,000 homology groups were identified with the help of Ensembl homolo...

The death-effector domain (DED) is a critical protein interaction domain that recruits caspases into complexes with members of the TNF-receptor superfamily. Apoptosis can also be induced by expressing certain DED-containing proteins without surface receptor cross-linking. Using Green Fluorescent Protein to examine DED-containing proteins in living cells, we show that these proteins cause apopto...

Adaptor protein FADD forms the death inducing signaling complex (DISC) by recruiting the initiating caspases-8 and -10 through homotypic death effector domain (DED) interactions. Cellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of death ligand-induced apoptosis downstream of death receptors, and FADD competes with procaspase-8/10 for recruitment for DISC. However, the mechanism of act...

The Optimal economic operation of their electric networks while considering the challenges of increasing fuel costs and increasing demand for electricity. The dynamic economic dispatch (DED) occupies important place in a power system’s operation and control. It aims to determine the optimal power outputs of on-line generating units in order to meet the load demand and reducing the fuel cost. Th...

Recent advances in the understanding of dry eye disease (DED) have revealed previously unexplored targets for drug therapy. One of these drugs is diquafosol, a uridine nucleotide analog that is an agonist of the P2Y2 receptor. Several randomized controlled trials have demonstrated that the application of topical diquafosol significantly improves objective markers of DED such as corneal and conj...

IMPORTANCE There are limited reports on the relationship between mucin 5AC (MUC5AC) concentrations in tears, working hours, and the frequency of ocular symptoms in visual display terminal (VDT) users. This investigation evaluated these relationships among patients with dry eye disease (DED) and individuals serving as controls. OBJECTIVE To determine the relationship between MUC5AC concentrati...

PURPOSE To determine cytokine and chemokine concentrations in the tears of patients with dry eye disease (DED) and analyze the possible relationships with the clinical severity of DED. METHODS Patients were examined using the Ocular Surface Disease Index, corneal and conjunctival staining, tear breakup time, and impression cytology. They were divided into four groups according to the Dry Eye ...

The DAG Edge Deletion problem of k, or DED(k), is to delete the minimum weight set of edges from a directed acyclic graph such that the remaining graph has no path of length k. In 2012, Svensson showed it was hard to approximate the vertex deletion version with a ratio better than k assuming the Unique Games Conjecture is true [14], and in 2015 Kenkre et al. introduced the DED(k) problem and us...

There is a clear association between dry eye disease (DED) and skin inflammatory diseases occurring in close proximity to the eyelids, such as facial skin rosacea. Intense pulsed light (IPL) is widely accepted as a treatment for skin rosacea. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of...

مکانیزم شکست ناشی از خزش در طی حادثه شدید یک رآکتور‌ آبی‌تحت‌فشار به‌جهت انتقال مواد رادیواکتیو به محیط‌زیست اهمیت ویژه‌ای برخوردار است. دنبال شدید، حرارت واپاشی منتقل‌شده سایر قسمت‌های سیستم‌خنک‌کننده رآکتور می‌تواند منجر گرم‌شدن سازه‌های سیستم خنک‌کننده (RCS) و خرابی نواحی تحت‌فشار آسیب‌پذیر شود. قطع‌کامل‌برق (SBO) بدون اقدامات اپراتور (توالی TMLB) یکی محتمل‌ترین سناریوهایی است که ممکن یکپارچ...