HCN channels are the molecular subunits of native funny (f-) channels of cardiac pacemaker cells and neurons. Although funny channels were first functionally described in cardiac cells in the late 1970s, cloning of HCN channels, of which four subunits are known today (HCN1-4), had to wait some 20 years to be accomplished, which delayed the investigation of HCN-related channelopathies. In cardia...

Cold-acclimated twigs of Amelanchier alnifolia Nutt. released less HCN at -4.5 C than nonacclimated twigs following slow freezing to -25 C or rapid freezing to -78 C. Cold-acclimated twigs frozen slowly to -25 C released more HCN than cold-acclimated twigs frozen only to -4.5 C. Cold-acclimated twigs frozen slowly to -25 C and then rapidly to -78 C released less HCN at -4.5 C than cold-acclimat...

An n-dimensional hierarchical cubic network (denoted by HCN(n)) contains 2 n n-dimensional hypercubes. The diameter of the HCN(n), which is equal to n+(n+1)/3+1, is about two-thirds the diameter of a comparable hypercube, although it uses about half as many links per node. In this paper, a maximal number of node-disjoint paths are constructed between every two distinct nodes of the HCN(n). Th...

The stem and bulb nematode (Ditylenchus dipsaci) is a serious quarantine pest of vegetables spreading worldwide via seed and planting material. Currently, a hot water technique is used as the pre-seed treatment, which is difficult to execute and the risk of seed damage is high. The objectives of this study were to evaluate the (a) penetration of gaseous hydrogen cyanide (HCN) into garlic tissue...

cAMP signaling in the brain mediates several higher order neural processes. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels directly bind cAMP through their cytoplasmic cyclic nucleotide binding domain (CNBD), thus playing a unique role in brain function. Neuronal HCN channels are also regulated by tetratricopeptide repeat-containing Rab8b interacting protein (TRIP8b), an aux...

Abstract. An imaging survey of CO(1−0), HCN(1−0), and HCO(1−0) lines in the centers of nearby Seyfert galaxies has been conducted using the Nobeyama Millimeter Array and the RAINBOW interferometer. Preliminary results reveal that 3 Seyferts out of 7 show abnormally high HCN/CO and HCN/HCO ratios, which cannot occur even in nuclear starburst galaxies. We suggest that the enhanced HCN emission or...

We use a multifluid hydrodynamical-chemical model of cometary comae to predict the HNC and HCN abundances in comets Hyakutake and Hale-Bopp for a variety of initial parameters. We find, in general, that the presence of methanol in the nuclear ices inhibits the synthesis of HNC from HCN through proton transfer reactions in the coma. For Hale-Bopp, we find that because of the large gas production...

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels underlie the cationic Ih current present in many neurons. The direct binding of cyclic AMP to HCN channels increases the rate and extent of channel opening and results in a depolarizing shift in the voltage dependence of activation. TRIP8b is an accessory protein that regulates the cell surface expression and dendritic local...

We present a search for HCN emission from four high redshift far infrared (IR) luminous galaxies. Current data and models suggest that these high z IR luminous galaxies represent a major starburst phase in the formation of spheroidal galaxies, although many of the sources also host luminous active galactic nuclei (AGN), such that a contribution to the dust heating by the AGN cannot be precluded...

We present here the sensitive HCN(1-0) observations made with the VLA of two submillimeter galaxies and two QSOs at high-redshift. HCN emission is the signature of dense molecular gas found in GMC cores, the actual sites of massive star formation. We have made the first detection of HCN in a submillimeter galaxy, SMM J16359+6612. The HCN emission is seen with a signal to noise ratio of 4σ and a...