The previous pharmacokinetic methods can be only limited to drug analysis in vitro, which provide less information on the distribution and metabolismof drugs, and limit the interpretation and assessment of pharmacokinetics, the determination of metabolic principles, and evaluation of treatment effect. The objective of the study was to investigate the pharmacokinetic characteristics of gene reco...

Monoclonal antibody therapy may provide new treatment options in the management of metastatic breast cancer by selectively targeting tumors and producing a therapeutic effect, by delivering radiation or other toxins directly to tumor cells, or by producing an intrinsic immune inflammatory response. The effect of 131I-labeled humanized anti-Lewis(y) monoclonal antibody 3S193 (hu3S193) was compar...

In article number 2000802 by Xinhui Su, Xiaolian Sun, and co-workers, a 131I labeled ZnPc(COOH)4 conjugated ZnGa2O4:Cr3+ nanoplatform (131I-ZGCs-ZnPcC4) is developed for in vivo radiotherapy (RT) radiation-induced photodynamic therapy (PDT). can not only activate ZGCs long-lasting luminescence which further continuously activates the photosensitizer PDT, but also directly kill cancerous cells. ...

The Treatment Paradigm (Figure 1) Methimazole (MMI) was started 3 to 6 months before 131I therapy to restore euthyroidism and was discontinued 5 days (T-5) before 131I was initiated. On the same day, lithium, 900 mg/day was started. Seven days after 131I was administered (day T0), lithium was withdrawn, comprising 12 days of lithium, and oral prednisone was started at 0.5 mg/kg daily to avoid 1...

Dedifferentiation of well-differentiated thyroid carcinoma is a well-known phenomenon that may lead to the disappearance of radioiodine uptake in tumors and the inability to treat patients with radioiodine. We report a patient in whom the 131I uptake progressively diminished to such low levels after a cumulative dose of 31.5 GBq that further 131I administration was considered nonbeneficial. The...

To the Editor: Earlier studies demonstrated unexpected decrease of radioiodine (131I) renal excretion in patients adherent to low-iodine diet before 131I treatment while receiving furosemide [1,2]. This effects seems specific for humans, since it was not confirmed in a study on mice treated with low-iodine diet [3]. Other researchers [4-7] observed increase of 131I uptake to thyroid tissue or t...

Monoclonal antibody (mAb) A33 reacts with an antigen expressed by >95% of colon cancer and normal colon epithelial cells. An earlier Phase I trial of 131I-labeled mAb A33 (131I-mAb A33) demonstrated bone marrow suppression as the dose-limiting toxicity, and although modest antitumor effects were seen, no normal colon toxicity was observed. In this study, a nude mouse model was used to test whet...

Patients suffering from multinodular toxic goiter (MNTG) are candidates to thyroidectomy or radioiodine 131I (131I) therapy. Thyroidectomy may be preferable especially when the volume of hyperfunctioning tissue is so large that a single administration of 131I is unlikely to cure the patient in terms of nodule's volume reduction and thyroid function. We describe the case of a 71-year-old man suf...

PURPOSE The aims of the current study were to explore plasma lncRNAs as a novel biomarker panel for the diagnosis of non-131I-avid lung metastases of PTC and to investigate the plasma lncRNA expression levels associated with survival in PTC patients with lung metastases. METHODS The expression of lncRNAs was examined using an lncRNA microarray chip. The lncRNAs with the most significant diffe...