BACKGROUND Identifying the potential for drug-induced kidney injury is essential for the successful research and development of new drugs. Newer and more sensitive preclinical drug-induced kidney injury biomarkers are now qualified for use in rat toxicology studies, but biomarkers for clinical studies are still undergoing qualification. The current studies investigated biomarkers in healthy vol...

For each vertex v in a graph G, let there be associated a subgraph Hv of G. The vertex v is said to dominate Hv as well as dominate each vertex and edge of Hv. A set S of vertices of G is called a full dominating set if every vertex of G is dominated by some vertex of S, as is every edge of G. The minimum cardinality of a full dominating set of G is its full domination number γFH(G). A full dom...

Spleen cells primed by Prospect Hill (PH) or Puumala (Pu) virus could cross-react with Hantaan virus (HV) 76-118 strain-infected target cells after in vitro stimulation with HV-infected cells, although anti-PH or anti-Pu immune serum showed no cross-reactive neutralizing (NT) activity to HV without complement. These results and our previous findings with cross-reactive cytotoxic T lymphocytes (...

Gene electrotransfer is gaining momentum as an efficient methodology for nonviral gene transfer. In skeletal muscle, data suggest that electric pulses play two roles: structurally permeabilizing the muscle fibers and electrophoretically supporting the migration of DNA toward or across the permeabilized membrane. To investigate this further, combinations of permeabilizing short high-voltage puls...

The extracellular matrix (ECM) environment plays a critical role in organism development and disease. Surface sensitive microscopy techniques for studying the structural and chemical properties of ECMs are often performed in high vacuum (HV) environments. In this report, we examine the affect HV conditions have on the bioactivity and mechanical properties of type I collagen fibrillar matrices. ...

We displayed backward/forward motion on a computer monitor in the ground plane. Subjects looked at the center of a moving pattern and eye movements of both eyes were recorded with a search coil system. Involuntary nystagmus including vertical version (VV) and horizontal vergence (HV) was recorded. Dynamics of the nystagmus showed that the slow and quick phase of VV and HV were always associated...

Liver tumors involving hepatic vein (HV) at caval confluence have been always considered an indication for major hepatectomy and/or HV reconstruction. However; careful study by means of intraoperative ultrasonography (IOUS) of tumor-vein relations and HV anatomy searching for accessory veins, together with color-Doppler IOUS analysis of portal flow, allows more conservative approaches also in t...

In situ observation of absorption spectral change of heptil viologen cation radical (HV ) was performed by slab optical waveguide (SOWG) spectroscopy utilizing indium-tin-oxide (ITO) electrodes. Synchronizing with electrochemical techniques, we observed the adsorption process of HV on the ITO electrode. In this study, we carried out the ITO-SOWG observations using KBr aqueous solution containin...

High multivitamin gestational diets (HV, 10-fold AIN-93G levels) increase body weight (BW) and food intake (FI) in rat offspring weaned to a recommended multivitamin (RV), but not to a HV diet. We hypothesized that high vitamin A (HA) alone, similar to HV, in post-weaning diets would prevent these effects of the HV maternal diet consistent with gene expression in FI and reward pathways. Male of...