PURPOSE Instrumental variable (IV) analysis can control for unmeasured confounding, yet it has not been widely used in pharmacoepidemiology. We aimed to assess the performance of IV analysis using different IVs in multiple databases in a study of antidepressant use and hip fracture. METHODS Information on adults with at least one prescription of a selective serotonin reuptake inhibitor (SSRI)...

Background—We tested the hypothesis that right ventricular (RV) pressure overload affects RV function and further influences left ventricular (LV) geometry, which adversely affects LV twist mechanics and segmental function. Methods and Results—Echocardiographic images were prospectively acquired in 44 patients (age, 46 12 years; 82% women) with evidence of pulmonary hypertension (estimated pulm...

This paper reviews recent developments in methods for dealing with weak instruments (IVs) in IV regression models. The focus is more on tests (and confidence intervals derived from tests) than estimators. The paper also presents new testing results under “many weak IV asymptotics,” which are relevant when the number of IVs is large and the coefficients on the IVs are relatively small. Asymptoti...

It has previously been shown that upon infection of HeLa cells with modified vaccinia virus Ankara (MVA), assembly is blocked at a late stage of infection and immature virions (IVs) accumulate (G. Sutter and B. Moss, Proc. Natl. Acad. Sci. USA 89:10847-10851, 1992). In the present study the morphogenesis of MVA in HeLa cells was studied in more detail and compared to that under two conditions t...

Synthetic ochre and amber tRNA suppressor genes derived from the yeast tRNA(PheGAA) sequence have been constructed. They were efficiently transcribed in vitro and expressed in vivo via a synthetic expression cassette. tRNA(PheUUA) and tRNA(PheUUA) delta IVS (IVS = intervening sequence) are relatively inefficient ochre suppressors. They are toxic to the cell when expressed on a multicopy plasmid...

Giriş ve Amaç: Adana, talasemi kuşağında yer alan açısından yüksek frekansa sahip bir şehirdir. Suriye’den ülkemize olan göçün yoğun kısmı Adana şehrine olmaktadır bunun sonucunda farklı tipte mutasyonları görülmeye başlanmıştır. Bu çalışmada, merkezimizde takip tedavi edilen beta majör tanılı Türkiyeli gelen hastaların globin gen mutasyon sonuçlarının değerlendirilmesi amaçlandı.
 Gereç Y...

* Associate Professor Department of Community, Occupational and Family Medicine National University of Singapore Address for Reprints: Dr Chia Kee Seng, Department of Community, Occupational and Family Medicine, National University of Singapore, Lower Kent Ridge Road, Singapore 119260. Introduction In modern medical research, it is rare to limit data analysis to merely two variables: a single e...

Sensitized T lymphocytes can mediate potent antitumor effects when transferred to tumor-bearing animals. Employing the MCA 105 and MCA 106 sarcomas, we were able to generate antitumor effector cells by immunization of syngeneic mice with tumor cells admixed with Corynebacterium parvum. These immune splenocytes could be further sensitized and expanded in culture by the in vitro sensitization (IV...

Polymorphisms in folate pathway genes may influence the susceptibility to acute lymphoblastic leukemia (ALL). DNA was isolated from 245 pediatric ALL patients (cases) and from 500 blood bank donors (controls). Polymorphisms in methylene-tetrahydrofolate reductase (MTHFR 677C>T, 1298A>C), methionine synthase (MTR 2756A>G), methionine synthase reductase (MTRR 66A>G), methylenetetrahydrofolate deh...