POP-1, a Tcf/Lef factor, functions throughout Caenorhabditis elegans development as a Wnt-dependent reiterative switch to generate nonequivalent sister cells that are born by anterior-posterior cell divisions. We have observed the interaction between POP-1 and a target gene that it represses as it responds to Wnt signaling. Dynamic observations in living embryos reveal that POP-1 undergoes Wnt-...

The design of the Parallel Ocean Program (POP) is described with an emphasis on portability. Performance of POP is presented on a wide variety of computational architectures, including vector architectures and commodity clusters. Analysis of POP performance across machines is used to characterize performance and identify improvements while maintaining portability. A new design of the POP model,...

Visual stimuli can "pop out" if they are different to their background. There has been considerable debate as to the role of primary visual cortex (V1) versus higher visual areas (esp. V4) in pop-out processing. Here we parametrically modulated the relative orientation of stimuli and their backgrounds to investigate the neural correlates of pop-out in visual cortex while subjects were performin...

This meta-analysis was conducted to estimate the association between matrix metalloproteinase-1 (MMP-1) expression and pelvic organ prolapse (POP) in women. Relevant studies published before 6 December 2015 were identified by searching PubMed, Ovid, EBSCO, and EMBASE. A total number of five case-control studies, including 182 POP cases and 192 controls, were identified. The results indicated th...

objective: urogynecologists are constantly looking for simple, safe and effective ways to cure vaginal apex prolapse. the aim of this study was to evaluate the results of posterior intravaginal slingplasty (pivs). materials and methods : a total of 38 patients with advanced vaginal apical prolapse underwent posterior intravaginal slingplasty in vali-e-asr hospital in tehran. in this clinical tr...

OBJECTIVE To investigate the presence of transforming growth factor-beta 1 (TGF-ß1) and connective tissue growth factor (CTGF) in women with pelvic organ prolapse (POP). METHODS This study was conducted from May to December 2009. Fifty patients with POP that underwent vaginal hysterectomy in the Department of Gynecology, Renmin Hospital of Wuhan University, Hubei, Wuhan, China were enrolled i...

Objective: Pelvic organ prolapse (POP) remains a great therapeutic challenge with no optimal treatment available. Tissue maintenance and remodeling are performed by fibroblasts, therefore altered cellular functionality may influence tissue quality. In this study, we evaluated functional characteristics of fibroblasts from tissues involved in POP. Study design: To rule out normal ageing tissue d...

C. elegans embryonic cells have a common anterior/posterior (a/p) polarity that is apparent in the localization of the transcription factor POP-1. The level of nuclear POP-1 remains high in the anterior daughters of dividing cells but is lowered in the posterior daughters. To generate POP-1 asymmetry, most early embryonic cells require contact with signaling cells that express the ligand MOM-2/...

Gestation and delivery can increase intra-abdominal pressure, which are well-known risk factors for Pelvic Organ Prolapse (POP). But the pathogenesis mechanism of POP remains unclear. Our previous research showed that the expression of glutathione peroxidase type 1 (GPX1) decreased in pelvic floor ligaments from POP patients, implying that oxidative stress (OS) may be related to POP. The aim of...

Population-III (Pop-III) starformation (SF) is thought to be quenched when the metallicity of the starforming gas has reached a critical level. At high redshift, when the general intergalactic medium (IGM) was enriched with metals, the fraction of primordial gas already collapsed in minihalos (above the Jeans mass but below the mass corresponding to the efficient atomic cooling threshold for SF...