To study the effects of modestly increased expression of aldosterone synthase (AS), we generated mice (AS(hi/hi)) by replacing the 3' untranslated region of AS mRNA with that from a stable mRNA. AS(hi/hi) mice on a normal-salt diet had 1.5 times the wild-type AS mRNA in adrenals, although their blood pressure and plasma aldosterone did not differ from wild-type mice. Changes in dietary salt did...

The exploration of the end of the Dark Ages will be one of the most exciting field of the next decade. While most of the proposed observations must await the next–generation telescopes, the observational window of the redshifted 21cm line offers the possibility to investigate the physics of reheating and reionization on a short term. Here we describe several possible signatures detectable in th...

' I'l.1. III. I.II. II. I, II I I II.IIII PiI i,I. HI Shi 1.1..ii ii.i. kn. i nominated Whliilngton ai ih< nail ol iIn II gulail) •. hi dull ,i in. .mil' , ,MII mending hi > flvi ,. ai i< n hi id "i i he University*! i in.in. ml "i" I>I i Sht I" hilling | hi. terved na «, II at > i.. |>ii idi HI I HI iiii.in. i II.i. I", v II.I SIM I ..II. ,il lli. in,,..l crealivi ad luiiaiom i havi worked ..m...

BACKGROUND As the global population ages, disabling hearing impairment (HI) have been increased rapidly. The impact of HI on health-related quality of life (HRQoL) is of great importance to aid the development of strategic plans and to guide therapeutic interventions. PURPOSE To evaluate HRQoL in Korean adults with different degrees of HI using EuroQol five-dimensional (EQ-5D) and EQ-visual a...